Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Ashley V. Menk Clear advanced filters

  • The tumour microenvironment is low in glucose and high in the alternative metabolite lactate, which regulatory T cells are shown here to use, maintaining their ability to suppress effector immune cells.

    • McLane J. Watson
    • Paolo D. A. Vignali
    • Greg M. Delgoffe
    Research
    Nature
    Volume: 591, P: 645-651

  • Exhausted CD8+ T cells with diminished effector functions accumulate in tumors. Here, the authors show that hypoxia induces a suppressive phenotype in exhausted T cells and that interfering with hypoxia-mediated CD39 expression limits immunosuppression in the tumor and augments immunotherapy, resulting in arrest of tumor growth.

    • Paolo D. A. Vignali
    • Kristin DePeaux
    • Greg M. Delgoffe
    Research
    Nature Immunology
    Volume: 24, P: 267-279

  • Germinal center B cells can undergo rapid proliferation. Shlomchik and colleagues show that germinal center B cells, unlike other rapidly proliferating cells, do not depend on glycolysis, but rather increase their peroxisome content and rewire their cellular metabolism to exclusively utilize fatty acid oxidation for their energetic needs.

    • Florian J. Weisel
    • Steven J. Mullett
    • Mark J. Shlomchik
    Research
    Nature Immunology
    Volume: 21, P: 331-342