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Showing 1–4 of 4 results
Advanced filters: Author: Ashling Giblin Clear advanced filters

  • Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels increased survival of Drosophila models of ALS/FTD and patient neurons, suggesting that interventions that increase neuronal PUFA levels in patients with ALS/FTD may also be beneficial.

    • Ashling Giblin
    • Alexander J. Cammack
    • Adrian M. Isaacs
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 737-747

  • The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.

    • Femke M. Feringa
    • Sascha J. Koppes-den Hertog
    • Rik van der Kant
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 2142-2164

  • C9orf72 ALS/FTD polyGR and polyPR knock-in mice show cortical hyperexcitability and motor neuron loss accompanied by an increase in extracellular matrix proteins in the spinal cord that is conserved in patient iPS cell-derived neurons and is neuroprotective.

    • Carmelo Milioto
    • Mireia Carcolé
    • Adrian M. Isaacs
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 643-655