Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Ashok Ragavendran Clear advanced filters

  • During sea urchin development, the micromeres form via asymmetric cell division and act as organizers to induce gastrulation. Here they show that micromeres have unique metabolic characteristics and that disrupting their metabolic activity blocks gastrulation induction.

    • Shakson Isaac
    • Douglas Dubosky
    • Mamiko Yajima
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Drugs that modify RNA splicing are promising treatments for many genetic diseases. Here the authors show that deep learning strategies can predict drug targets, strongly supporting the use of in silico approaches to expand the therapeutic potential of drugs that modulate RNA splicing.

    • Dadi Gao
    • Elisabetta Morini
    • Susan A. Slaugenhaupt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Recurrent, reciprocal genomic disorders due to non-allelic homologous recombination (NAHR) are a major cause of human disease. The authors developed a CRISPR/Cas9 genome engineering method that directly targets segmental duplications and efficiently mimics the NAHR-mediated mechanism of microdeletion and microduplication that occurs in vivo using 16p11.2 and 15q13.3 as proof-of-principle models.

    • Derek J C Tai
    • Ashok Ragavendran
    • Michael E Talkowski
    Research
    Nature Neuroscience
    Volume: 19, P: 517-522