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Showing 1–3 of 3 results

Advanced filters: Author: Ashot Papikian Clear advanced filters

CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis

Binenbaum et al. demonstrate that precise CRISPR-based targeting of a key chromatin mark (H3K4me3) can switch on genes, boost disease resistance, and unlock meiotic recombination in plants, opening new routes for crop improvement.

Jenia Binenbaum
Vanda Adamkova
C. Jake Harris
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis

This study revealed that targeting H3K4me3 via the H3K4 methyltransferase SDG2 activates gene expression and removes DNA methylation by recruiting DNA demethylases. Conversely, the removal of H3K4me3 synergistically enhances targeted DNA methylation.

Ming Wang
Yan He
Steven E. Jacobsen
ResearchOpen Access11 Feb 2025
Nature Plants

Volume: 11, P: 206-217
Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems

Few approaches for targeted manipulation of the epigenome are available in plants. Here, the authors adapt the dCas9-SunTag system to engineer targeted gene activation and site-specific manipulation of DNA methylation in Arabidopsis.

Ashot Papikian
Wanlu Liu
Steven E. Jacobsen
ResearchOpen Access13 Feb 2019
Nature Communications

Volume: 10, P: 1-11