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Showing 1–5 of 5 results
Advanced filters: Author: Ashraf Al-Amoudi Clear advanced filters

  • Al-Amoudi and Baradaran et. al. show that cryo-ultramicrotomy can produce vitreous sections as thin as ~40 nm with minimal surface damage, overcoming limitations imposed by focused ion beam–milled lamellae. Using these ultrathin sections, they determine high-resolution, side-chain-level structures of the 50S ribosomal subunit both in vitro (2.8 Å) and in situ (3 Å).

    • Ashraf Al-Amoudi
    • Rozbeh Baradaran
    • Andreas Naschberger
    ResearchOpen Access
    Communications Biology
    P: 1-13

  • Using a newly developed biochemical method for aggregated protein extraction, Laferrière and colleagues uncover different neurotoxic types of pathologic TDP-43 assemblies in the brains of subjects with distinct subtypes of frontotemporal dementia.

    • Florent Laferrière
    • Zuzanna Maniecka
    • Magdalini Polymenidou
    Research
    Nature Neuroscience
    Volume: 22, P: 65-77

  • Cryo-electron tomography of vitreous section from human skin is used to investigate the architecture of cadherin molecules in desmosomes under near native conditions. Three-dimensional reconstructions and fitting of existing X-ray crystallography data reveal a regular array of molecules in desmosomes, that is consistent with data derived previously using different methods.

    • Ashraf Al-Amoudi
    • Daniel Castaño Díez
    • Achilleas S. Frangakis
    Research
    Nature
    Volume: 450, P: 832-837

  • Various endogenous and pathogen-derived stimuli trigger the assembly of cytosolic multimolecular 'speck' platforms coordinated by the adapter ASC. Latz and colleagues demonstrate that ASC specks have extracellular functions that can prolong inflammation.

    • Bernardo S Franklin
    • Lukas Bossaller
    • Eicke Latz
    Research
    Nature Immunology
    Volume: 15, P: 727-737