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Showing 1–3 of 3 results
Advanced filters: Author: Ashraf Ul Kabir Clear advanced filters

  • Tumour-associated blood vessels are abnormal in structure and function, and this can limit immune cell infiltration into tumours and contribute to the immunosuppressive tumour microenvironment. This Review highlights how tumour angiogenesis impacts antitumour immunity and explains why combining anti-angiogenic strategies with immunotherapies could improve clinical outcomes for patients with cancer.

    • Ashraf Ul Kabir
    • Madhav Subramanian
    • Kyunghee Choi
    Reviews
    Nature Reviews Immunology
    Volume: 26, P: 35-51

  • The transcriptional repressor Zbtb46 is expressed by DCs and endothelial cells. In this study, Choi and colleagues find downregulation of Zbtb46 confers a pro-tumor program in the vasculature and hematopoietic system, by promoting angiogenesis and the development of immunosuppressive myeloid cells.

    • Ashraf Ul Kabir
    • Carisa Zeng
    • Kyunghee Choi
    Research
    Nature Immunology
    Volume: 25, P: 1546-1554