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Showing 1–2 of 2 results
Advanced filters: Author: Ashton Trey Belew Clear advanced filters

  • Programmed −1 ribosomal frameshifting (−1 PRF) is a process by which a signal in a messenger RNA causes a translating ribosome to shift by one nucleotide, thus changing the reading frame; here −1 PRF in the mRNA for the co-receptor for HIV-1, CCR5, is stimulated by two microRNAs and leads to degradation of the transcript by nonsense-mediated decay and at least one other decay pathway.

    • Ashton Trey Belew
    • Arturas Meskauskas
    • Jonathan D. Dinman
    Research
    Nature
    Volume: 512, P: 265-269

  • Mechanisms underlying treatment failure of antileishmanial therapy are unclear. Here the authors provide transcriptome data of innate immune cells from cutaneous leishmaniasis patients undergoing treatment and find that a heightened type-I interferon response is associated with treatment failure.

    • María Adelaida Gómez
    • Ashton Trey Belew
    • Najib M. El-Sayed
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14