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Correction: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet

Andrew G. Levine
Alejandra Mendoza
Alexander Y. Rudensky
Amendments and Corrections05 Oct 2017
Nature

Volume: 550, P: 142
Smith-specific regulatory T cells halt the progression of lupus nephritis

Antigen specific regulatory T cells (Treg) play key roles in the peripheral tolerance to suppress autoreactive immune cells and represent potential avenue for therapeutic intervention. Here the authors identify Smith specific Treg and engineer Treg based cell therapy showing suppression of inflammation in a murine model of lupus nephritis.

Peter J. Eggenhuizen
Rachel M. Y. Cheong
Joshua D. Ooi
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T_H2 responses

This paper shows that regulatory T (T_reg) cells express the transcription factor IRF4, which is essential for the differentiation of T_H2 effector cells. IRF4 depletion in T_reg cells induces T_H2-driven autoimmune disease, leading the authors to suggest that IRF4 directs a module within T_reg cells that selectively suppresses T_H2 responses.

Ye Zheng
Ashutosh Chaudhry
Alexander Y. Rudensky
Research01 Feb 2009
Nature

Volume: 458, P: 351-356
Stability and function of regulatory T cells expressing the transcription factor T-bet

Regulatory T cells expressing the transcription factor T-bet selectively suppress T_H1 and CD8 T cells, but not T_H2 or T_H17 activation and associated autoimmunity.

Andrew G. Levine
Alejandra Mendoza
Alexander Y. Rudensky
Research07 Jun 2017
Nature

Volume: 546, P: 421-425
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Immune homeostasis relies on tight control over the size of a population of regulatory T cells (T_reg) that can suppress over-exuberant immune responses. Cells commit to the T_reg lineage by upregulating the transcription factor Foxp3. Conserved non-coding DNA sequence elements at the Foxp3 locus are now shown to control the composition, size and maintenance of the T_reg cell population.

Ye Zheng
Steven Josefowicz
Alexander Y. Rudensky
Research13 Jan 2010
Nature

Volume: 463, P: 808-812
Transcription factor Foxp3 and its protein partners form a complex regulatory network

The transcription factor Foxp3 is essential for the function of regulatory T cells. Rudensky and colleagues show Foxp3 participates in large protein complexes that regulate gene expression of many of these components in self-reinforcing networks.

Dipayan Rudra
Paul deRoos
Alexander Y Rudensky
Research26 Aug 2012
Nature Immunology

Volume: 13, P: 1010-1019
Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Rajiv V. Dave
Baek Kim
Zaid Al-Ishaq
ResearchOpen Access25 Mar 2021
British Journal of Cancer

Volume: 124, P: 1785-1794

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Correction: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet

Smith-specific regulatory T cells halt the progression of lupus nephritis

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T_H2 responses

Stability and function of regulatory T cells expressing the transcription factor T-bet

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

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Correction: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet

Smith-specific regulatory T cells halt the progression of lupus nephritis

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Stability and function of regulatory T cells expressing the transcription factor T-bet

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Search

Quick links

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T_H2 responses