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Showing 1–8 of 8 results
Advanced filters: Author: Ashwin Jainarayanan Clear advanced filters

  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis involving evasion of immune control. Here, the authors perform a comprehensive analysis of single-cell multi-omic data revealing either a myeloid-enriched or adaptive-enriched tumour microenvironment, linked to distinct B and T cell clonal selection and differentiation, distinct overall survival, and potential therapeutic approaches.

    • Shivan Sivakumar
    • Ashwin Jainarayanan
    • Rachael Bashford-Rogers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS carry specialized cargos distinct from constitutive extracellular vesicles to serve as intercellular messengers.

    • Pablo F. Céspedes
    • Ashwin Jainarayanan
    • Michael L. Dustin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Eighteen years after its inception, the international Genetically Engineered Machine competition has catalyzed the infusion of synthetic biology with interdisciplinary fundamental and translational research, as well as with inspired young scientists.

    • Ashwin K. Jainarayanan
    • Anastasios Galanis
    • Roger Rubio-Sánchez
    Comments & Opinion
    Nature Biotechnology
    Volume: 39, P: 1599-1601

  • In this Resource, Buckley and colleagues profile patients with Crohn’s disease and ulcerative colitis before and after adalimumab therapy. Specific pretreatment differences in the epithelial and myeloid compartments were associated with remission outcomes in both diseases. The authors also describe the cellular circuitry in nonremission patients following treatment.

    • Tom Thomas
    • Matthias Friedrich
    • Christopher D. Buckley
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 2152-2165

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29