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Showing 1–6 of 6 results
Advanced filters: Author: Ashwini Jambhekar Clear advanced filters

  • p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.

    • Jacob Stewart-Ornstein
    • Yoshiko Iwamoto
    • Galit Lahav
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Histone methylation regulates gene expression throughout animal development, governing processes as diverse as cell fate decisions, lineage specification, body patterning and organogenesis. Better understanding of the complex, context-specific roles of histone methylation in development will shed new light on the aetiology of developmental disorders.

    • Ashwini Jambhekar
    • Abhinav Dhall
    • Yang Shi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 625-641

  • Following DNA damage, the transcription factor p53 determines whether cells undergo apoptosis or cell cycle arrest and DNA repair. To enable different cellular outcomes, p53 is regulated through its temporal expression dynamics and post-translational modification, and by interactions with chromatin, chromatin regulators and transcription factors.

    • Antonina Hafner
    • Martha L. Bulyk
    • Galit Lahav
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 199-210