This study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
- Aishwarya Omble
- Shrutika Mahajan
- Kiran Kulkarni
