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Showing 1–4 of 4 results
Advanced filters: Author: Asier Echarri Clear advanced filters

  • Adipose tissue accommodates large volume changes upon expansion, but the molecular mechanisms involved are not fully understood. Here, Aboy et al. describe CAV1 Y14 phosphorylation as required for appropriate adipocyte caveolae flattening and homeostasis.

    • María C. M. Aboy-Pardal
    • Marta C. Guadamillas
    • Miguel A. Del Pozo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • Lolo et al. show caveolin-1 functions in non-caveolae structures termed dolines. Whereas caveolae respond to high forces over a mechanical threshold, dolines transduce low and medium mechanical forces gradually in a complementary buffering system.

    • Fidel-Nicolás Lolo
    • Nikhil Walani
    • Miguel A. del Pozo
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 120-133

  • The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP then controls Importin-7 response to mechanical cues and restricts Importin-7 binding to other cargoes.

    • María García-García
    • Sara Sánchez-Perales
    • Miguel A. Del Pozo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Mechanical forces are sensed by cells and can alter plasma membrane properties, but biochemical changes underlying this are not clear. Here the authors show tension is sensed by c-Abl and FBP17, which couples changes in mechanical tension to remodelling of the plasma membrane and actin cytoskeleton.

    • Asier Echarri
    • Dácil M. Pavón
    • Miguel A. Del Pozo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16