Proper establishment, maintenance and removal of covalent post-translational modifications on histones are essential for normal cell physiology. In this issue, Nicolas et al. describe the characterization of two physically and functionally distinct Clr6 (Rpd3)-containing histone deacetylase complexes in fission yeast and implicate their activity in a number of processes, including transcriptional regulation, silencing and genomic integrity.
- Assen Roguev
- Nevan J Krogan
