Nature Search

Functional synapses between neurons and small cell lung cancer

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

Vignesh Sakthivelu
Anna Schmitt
Filippo Beleggia
ResearchOpen Access10 Sept 2025
Nature

Volume: 646, P: 1243-1253
Publisher Correction: Functional synapses between neurons and small cell lung cancer

Vignesh Sakthivelu
Anna Schmitt
Filippo Beleggia
Amendments and CorrectionsOpen Access19 Sept 2025
Nature

Volume: 646, P: E17
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction

CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and epigenetically regulating nuclear stiffness.

Harshita Kaul
Lea Isermann
Aleksandra Trifunovic
ResearchOpen Access01 Aug 2025
Nature Metabolism

Volume: 7, P: 1593-1613
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

Mitochondrial quality control mechanisms prevent damage accumulation, including in mitochondrial DNA (mtDNA). Here, Sen et al. show that altered mtDNA elicits local rearrangements in mitochondrial membrane potential and cristae structure, with mtDNA eliminated through VPS35 endosomes.

Ayesha Sen
Sebastian Kallabis
David Pla-Martín
ResearchOpen Access07 Nov 2022
Nature Communications

Volume: 13, P: 1-20
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the granular layer 2.

Matthias Rübsam
Aaron F. Mertz
Carien M. Niessen
ResearchOpen Access01 Nov 2017
Nature Communications

Volume: 8, P: 1-16
Selective Capture and Purification of MicroRNAs and Intracellular Proteins through Antisense-vectorized Magnetic Nanobeads

Isabel Gessner
Xiaojie Yu
Sanjay Mathur
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition

Wilhelm Stoffel
Ina Hammels
Frank Zaucke
ResearchOpen Access24 Nov 2016
Cell Death & Disease

Volume: 7, P: e2488

Search

Filter By:

Functional synapses between neurons and small cell lung cancer

Publisher Correction: Functional synapses between neurons and small cell lung cancer

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

Selective Capture and Purification of MicroRNAs and Intracellular Proteins through Antisense-vectorized Magnetic Nanobeads

Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition

Search

Quick links