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Advanced filters: Author: Asvin Lakkaraju Clear advanced filters

  • The H-latch is a well-defined structural change occurring in PrPC bound to the neurotoxic antibody POM1, and its presence shows a positive correlation with neurotoxicity. Inhibition of the H-latch prolongs the lifespan of prion-diseased mice.

    • Karl Frontzek
    • Marco Bardelli
    • Adriano Aguzzi
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 831-840