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Showing 1–2 of 2 results
Advanced filters: Author: Aswanth H. Mahalingam Clear advanced filters

  • Basal Pancreatic Ductal Adenocarcinoma (PDAC) is more aggressive than the classical subtype of pancreatic cancer. Here the authors report that RNA-binding protein LIN28B and its target HMGA2 drive basal PDAC pathogenesis by reducing PP2A methylation and activity, resulting in enhanced protein synthesis and aggressive features.

    • Stephanie Dobersch
    • Naomi Yamamoto
    • Sita Kugel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Characterising the molecular profile of soft tissue sarcomas (STS) remains critical. Here, the authors analyse samples from 321 STS patients across 11 histological subtypes using proteomics and identify prognostic signatures that can be applied to multiple subtypes.

    • Jessica Burns
    • Christopher P. Wilding
    • Paul H. Huang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17