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Showing 1–6 of 6 results
Advanced filters: Author: Athanasia Mizi Clear advanced filters

  • Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule substrates, beyond proteins. This discovery may be harnessed to develop specific tool substrates or inhibitors of HECT-type ligases.

    • Barbara Orth
    • Pavel Pohl
    • Sonja Lorenz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Adult pluripotent stem cells, called neoblasts, are considered a defining feature of all flatworms. This manuscript shows that canonical neoblasts are absent in an early branching flatworm lineage, raising important questions about the evolution of neoblasts.

    • Ludwik Gąsiorowski
    • Chew Chai
    • Jochen C. Rink
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Using CRISPR-guided editing, Liesenfelder et al. modify DNA methylation at epigenetic clock sites, which evokes genome-wide age-associated epigenetic modifications. Their findings suggest age-associated DNA methylation changes can be coherently modified within an epigenetic network.

    • Sven Liesenfelder
    • Mohamed H. Elsafi Mabrouk
    • Wolfgang Wagner
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 997-1009

  • Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a clinical mutation that affects its ability to recruit cofactors, leading to impaired autophagy induction and DNA repair.

    • Yulia Kargapolova
    • Rizwan Rehimi
    • Argyris Papantonis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15