Majority of biologic drugs and vaccines require temperature-controlled conditions throughout the supply chain to minimize thermal inactivation and contamination, which is costly and impractical. Here, the authors report chemical dispersants that non-covalently solvate proteins within fluorous liquids, resulting in non-aqueous, fluorine-based liquid protein formulations that biochemically rigidify protein structure to yield thermally stable biologics that are also resistant to degradation.
- Atip Lawanprasert
- Harminder Singh
- Scott H. Medina
