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Showing 1–12 of 12 results
Advanced filters: Author: Aubree Gordon Clear advanced filters

  • Human metapneumovirus (hMPV) can cause severe acute respiratory illness in children but effective therapeutic monoclonal antibodies require further exploration. The authors here isolate a panel of monoclonal antibodies from children previously infected with hMPV, test their in vitro neutralizing potency, reveal their cryo-EM structures and manifest their in vivo prophylactic efficacy.

    • Ahmed Magdy Khalil
    • Behrouz Ghazi Esfahani
    • Jarrod J. Mousa
    ResearchOpen Access
    Nature Communications
    P: 1-14

  • Understanding the dual role of neuraminidase and hemagglutinin antibodies in influenza transmission is crucial for enhancing vaccine efficacy. Here, the authors use household transmission studies and mathematical models and find that neuraminidase immunity reduces infectivity, suggesting vaccines targeting both glycoproteins could lower community transmission and offer broader protection.

    • Gregory Hoy
    • Thomas Cortier
    • Aubree Gordon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The extent to which SARS-CoV-2 serum neutralising antibodies are informative as correlates of protection for Omicron strains is uncertain. Here, the authors use data from a household-based prospective cohort study in Nicaragua to investigate correlates of protection against infection and symptomatic infection for Omicron BA.1 and BA.2.

    • José Victor Zambrana
    • Ian A. Mellis
    • Aubree Gordon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8

  • Here Wraith et al. report homotypic protection from repeated influenza infection in a prospective pediatric cohort in Nicaragua followed for 9 years. This protection is observed across multiple seasons, subtypes, and lineages and is consistent for older and younger children.

    • Steph Wraith
    • Angel Balmaseda
    • Aubree Gordon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Lack of knowledge of individual infection history hinders understanding of immunological interactions among DENV serotypes. Here, the authors introduce a framework to infer the relationship between unobserved infection history and subsequent infection and disease risk, and find complex dependencies.

    • Tim K. Tsang
    • Samson L. Ghebremariam
    • Yang Yang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Isolates of authentic SARS-CoV-2 variants BA.1 and BA.2 exhibit similar infectivity and pathogenicity and show susceptibility to neutralizing therapeutic antibodies and antiviral compounds in mouse and hamster models.

    • Ryuta Uraki
    • Maki Kiso
    • Yoshihiro Kawaoka
    Research
    Nature
    Volume: 607, P: 119-127

  • A severe acute respiratory syndrome coronavirus 2 Omicron subvariant, BA.2.86, was found to be no more resistant to human sera than the currently dominant XBB.1.5 and EG.5.1, but it had a remarkably higher receptor affinity.

    • Qian Wang
    • Yicheng Guo
    • David D. Ho
    Research
    Nature
    Volume: 624, P: 639-644

  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
    Reviews
    Nature
    Volume: 605, P: 640-652