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Showing 1–7 of 7 results
Advanced filters: Author: Aubrey V. Weigel Clear advanced filters

  • Focused ion beam scanning electron microscopy (FIB-SEM) combined with deep-learning-based segmentation is used to produce three-dimensional reconstructions of complete cells and tissues, in which up to 35 different organelle classes are annotated.

    • Larissa Heinrich
    • Davis Bennett
    • Destiny Nguyen
    Research
    Nature
    Volume: 599, P: 141-146

  • Bharathan et al. discover that the endoplasmic reticulum associates with keratin intermediate filaments and desmosomal cell–cell junctions, and that desmosomes and the keratin cytoskeleton regulate the distribution, dynamics and function of the endoplasmic reticulum network.

    • Navaneetha Krishnan Bharathan
    • William Giang
    • Andrew P. Kowalczyk
    Research
    Nature Cell Biology
    Volume: 25, P: 823-835

  • Cells in many tissues fuse into syncytia acquiring new functions. By investigating whether physical remodelling promotes differentiation, here, the authors show that plasma membrane diminution post-fusion causes transient nutrient stress that inhibits YAP1 activity and may reduce proliferation-promoting transcription.

    • Daniel Feliciano
    • Carolyn M. Ott
    • Jennifer Lippincott-Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Volume electron microscopy techniques are high-resolution imaging approaches that reveal the 3D structure of cells, tissues and small model organisms at nanometre resolution. This Primer introduces the different imaging modalities, specialized sample processing and key applications in biosciences.

    • Christopher J. Peddie
    • Christel Genoud
    • Lucy M. Collinson
    Reviews
    Nature Reviews Methods Primers
    Volume: 2, P: 1-23