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Showing 1–3 of 3 results
Advanced filters: Author: Aude Anais Olijnik Clear advanced filters

  • Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by acetylation.

    • Andrew J. King
    • Duantida Songdej
    • Christian Babbs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • This protocol can be used to generate three-dimensional vascularized bone marrow organoids from human induced pluripotent stem cells. The organoids contain key stromal and hematopoietic cell types and can be engrafted with normal and malignant cells from adult donors to model niche interactions.

    • Aude-Anais Olijnik
    • Antonio Rodriguez-Romera
    • Abdullah O. Khan
    Protocols
    Nature Protocols
    Volume: 19, P: 2117-2146