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Nature Communications (2)
Nature Metabolism (1)

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Showing 1–3 of 3 results

Advanced filters: Author: Aude Angelini Clear advanced filters

CRAT links cholesterol metabolism to innate immune responses in the heart

Mao et al. show that deficiency in CRAT, a key determinant of metabolic flexibility, triggers type I interferon responses and AIM2 inflammasome activation by promoting the bile acid synthesis pathway in cardiomyocytes.

Hua Mao
Aude Angelini
Liang Xie
Research13 Jul 2023
Nature Metabolism

Volume: 5, P: 1382-1394
Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin

The vascular endothelium contributes to metabolic regulation, however, the underlying mechanisms are not fully understood. Here the authors show that endothelial low-density lipoprotein receptor-related protein 1 regulates glucose homeostasis via osteocalcin expression.

Hua Mao
Luge Li
Xinchun Pi
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-12
Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance

Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insulin resistance and hyperglycemia in diabetic mice.

Hua Mao
Luge Li
Xinchun Pi
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-10