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Showing 1–7 of 7 results
Advanced filters: Author: Aude Panatier Clear advanced filters

  • The molecular interplay between metabolic and synaptic functions of astrocytes is underexplored. Here, the authors show that astrocyte cannabinoid type-1 receptors integrate lactate and D-serine signaling to promote NMDA receptor-dependent cognition.

    • Ignacio Fernández-Moncada
    • Gianluca Lavanco
    • Giovanni Marsicano
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Astrocytic Ca2+ signals can be fast and local, supporting the idea that astrocytes have the ability to regulate single synapses. Here, the authors report the organization of astrocytes at nanoscale level and identify nodes as a functional astrocytic component of tripartite synapses.

    • Misa Arizono
    • V. V. G. Krishna Inavalli
    • U. Valentin Nägerl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The authors find that glutamate release increases the diffusion of the astrocytic glutamate transporter GLT-1 in the plasma membrane. This activity-dependent increase in mobility facilitates glutamate clearance from the synaptic cleft, which influences the kinetics of excitatory post-synaptic events in rat hippocampal neurons.

    • Ciaran Murphy-Royal
    • Julien P Dupuis
    • Stéphane H R Oliet
    Research
    Nature Neuroscience
    Volume: 18, P: 219-226

  • In mice, persistent activation of mitochondrial cannabinoid receptors in astroglia impairs cellular glucose metabolism and lactate production, leading to an increase in redox stress in neurons and altered behavioural responses.

    • Daniel Jimenez-Blasco
    • Arnau Busquets-Garcia
    • Giovanni Marsicano
    Research
    Nature
    Volume: 583, P: 603-608

  • Astrocytes have been shown to regulate glutamatergic transmission in the brain. Here, the authors show that astrocytes also detect and modulate GABAergic transmission from somatostatin but not parvalbumin-positive interneurons, thus regulating dendritic inhibition via a feedback loop.

    • Marco Matos
    • Anthony Bosson
    • Jean-Claude Lacaille
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Good–bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

    • Carole Escartin
    • Elena Galea
    • Alexei Verkhratsky
    Reviews
    Nature Neuroscience
    Volume: 24, P: 312-325