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Showing 1–8 of 8 results
Advanced filters: Author: Aude Thiriot Clear advanced filters

  • Immune cells are generally considered to be able to move through tissues using nonadhesive amoeboid migration mechanics. Here, the authors show that, unlike other immune cells, mast cells do not use this method and instead are completely reliant on integrin–ECM interactions.

    • Lukas Kaltenbach
    • Paloma Martzloff
    • Tim Lämmermann
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 915-924

  • Spinal cord injury causes life-threatening infections. The authors report that this is partially mediated by a maladaptive neuroendocrine reflex, extending from the spinal cord to the adrenal glands, where it blocks catecholamines while producing immunosuppressive corticosteroids. The effect depends on the spinal injury level, and normalization of hormones production by the adrenals rescued mice from pneumonia.

    • Harald Prüss
    • Andrea Tedeschi
    • Jan M Schwab
    Research
    Nature Neuroscience
    Volume: 20, P: 1549-1559

  • Genetic polymorphisms affect expression of the atypical chemokine receptor ACKR1 (Duffy) on nucleated erythrocyte precursors. Rot and colleagues show that loss of its expression alters hematopoiesis, yielding a distinct neutrophil population that rapidly exits the bloodstream to give an apparent ‘neutropenia’ phenotype.

    • Johan Duchene
    • Igor Novitzky-Basso
    • Antal Rot
    Research
    Nature Immunology
    Volume: 18, P: 753-761

  • The regenerative capacity of the lung in response to injury deteriorates with aging. Here, Raslan et al. discover that aging-associated progressive lung fibrosis is accompanied by persistent activation of blood vessels. The authors identified the vascular YAP/TrkB axis as a putative driver of this process and potential therapeutic target.

    • Ahmed A. Raslan
    • Tho X. Pham
    • Giovanni Ligresti
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • T cells are selected in the thymus, through interaction with self-antigens, to remove autoreactive cells. Here the authors show that a specialized thymic dendritic cell subset juxtaposes to microvessels, requires CX3CR1/CX3CL1 for this positioning, and has processes extruding into the blood stream to sample soluble macromolecules and assist in T cell selection.

    • Elisabeth H. Vollmann
    • Kristin Rattay
    • Ulrich H. von Andrian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • In mice, it is possible to induce a psoriasis-like condition by applying imiquimod; here, the production of interleukin-23 that is stimulated by such skin inflammation is shown to depend on the interaction of nociceptors expressing the Nav1.8 and TRPV1 channels with skin-resident dendritic cells.

    • Lorena Riol-Blanco
    • Jose Ordovas-Montanes
    • Ulrich H. von Andrian
    Research
    Nature
    Volume: 510, P: 157-161