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Showing 1–6 of 6 results
Advanced filters: Author: Audrey Kauffmann Clear advanced filters

  • Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.

    • Melusine Bleu
    • Swann Gaulis
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • The original Cancer Cell Line Encyclopedia (CCLE) is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data.

    • Mahmoud Ghandi
    • Franklin W. Huang
    • William R. Sellers
    Research
    Nature
    Volume: 569, P: 503-508

  • A screen for compounds that may inhibit the growth of hematological malignancies reveals the specific dependence of some mantle cell lymphoma (MCL) cell lines on canonical or alternative NF-κB signaling. As also seen in patients, genetic alterations affecting alternative NF-κB signaling confer insensibility to ibrutinib, a compound that was recently approved for MCL treatment. This alternative signaling pathway underscores the need to tailor treatments to the specific driving pathways in each patient group.

    • Rami Rahal
    • Mareike Frick
    • Frank Stegmeier
    Research
    Nature Medicine
    Volume: 20, P: 87-92

  • In panels of cancer cell lines analysed for their response to drug libraries, some studies have proposed distinct pharmacological sensitivities for some cell lines while other studies have not seen the same trends; here the data in the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer are reassessed, and the authors report a stronger degree of concordance between the two data sets than that in a previous study.

    • Nicolas Stransky
    • Mahmoud Ghandi
    • Julio Saez-Rodriguez
    Research
    Nature
    Volume: 528, P: 84-87