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Showing 1–2 of 2 results
Advanced filters: Author: Audrey Olshefsky Clear advanced filters

  • Roy et al. describe a generalized method for computationally designing miniproteins selective for a single integrin heterodimer and conformational state. The designed αvβ6 inhibitor remains monomeric and maintains biological activity following aerosolization and shows excellent efficacy in bleomycin induced lung fibrosis.

    • Anindya Roy
    • Lei Shi
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strengthened through structure-based design.

    • Daniel Ellis
    • Julia Lederhofer
    • Masaru Kanekiyo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16