Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Audrone Lapinaite Clear advanced filters

  • In molecular biology, few molecules have had as profound an impact as Cas9. Madeleine King, Kayla Perry, Mitchell McAndrew and Audrone Lapinaite discuss how this multifunctional molecular tool of genetic engineering is revolutionizing multiple fields.

    • Madeleine B. King
    • Kayla N. Perry
    • Audrone Lapinaite
    Comments & Opinion
    Nature Chemistry
    Volume: 16, P: 1034

  • Research shows how small nuclear RNAs act as a cellular GPS to guide endogenous RNA-modifying enzymes to their targets for site-specific RNA editing. This approach boosts efficiency and safety when editing high-complexity genes, broadening the therapeutic potential.

    • Ieva Savickyte
    • Aashish Shivkumar
    • Audrone Lapinaite
    News & Views
    Nature Chemical Biology
    P: 1-2

  • Natural ribozymes can cleave RNA and single-stranded DNA (ssDNA) by transesterification or a blend of hydrolytic and transesterification reactions. Now, ribozymes have been discovered that catalyze the hydrolytic cleavage of ssDNA. Similar ribozymes could potentially replace large, immunogenic, protein-based nucleases in gene therapies.

    • Madeleine B. King
    • Audrone Lapinaite
    News & Views
    Nature Chemical Biology
    Volume: 20, P: 664-665

  • Methylation of H3K27 by Polycomb repressive complex 2 (PRC2) is essential for gene regulation. A new study provides structural evidence for the recognition of di- and trimethylated H3K36 by the Tudor domain of PRC2 subunit Phf19 as well as functional data suggesting that recognition of di- or trimethylated Phf19–H3K36 is required for regulating PRC2 activity and for full repression of selected PRC2 targets in embryonic stem cells.

    • Cecilia Ballaré
    • Martin Lange
    • Luciano Di Croce
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1257-1265

  • RNAs undergo many types of post-transcriptional modification, including methylation of ribosomal RNAs; here the structure of the archaeal box C/D ribonucleoprotein complex bound to substrate RNA is determined, showing that the two methylation guide sequences exist in different contexts and revealing sequential regulation of methylation at the two sites.

    • Audrone Lapinaite
    • Bernd Simon
    • Teresa Carlomagno
    Research
    Nature
    Volume: 502, P: 519-523

  • Chemical modifications of CpG dinucleotides form part of the epigenetic code and various methods for the detection of modified CpG sites exist. Here Kriukiene and colleagues report a complementary method that allows the profiling of unmodified CpG sites within the genome, which they call the 'unmethylome'.

    • Edita Kriukienė
    • Viviane Labrie
    • Saulius Klimašauskas
    Research
    Nature Communications
    Volume: 4, P: 1-10