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Showing 1–2 of 2 results
Advanced filters: Author: Aurora I. Idilli Clear advanced filters

  • Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumulation at stalled forks followed by replication protein A exhaustion and cell death.

    • Tyler H. Stanage
    • Shudong Li
    • Simon J. Boulton
    ResearchOpen Access
    Nature Cell Biology
    P: 1-15

  • ~15% of cancers induce alternative lengthening of telomeres (ALT) to activate telomere maintenance. Here, the authors reveal that infection with Kaposi’s sarcoma herpesvirus (KSHV) induces acquisition of ALT-like features in previously non-ALT cell lines.

    • Timothy P. Lippert
    • Paulina Marzec
    • Simon J. Boulton
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11