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Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing

A hybrid extracellular matrix–hydrogel with tunable mechanical stiffness and biochemical composition of young or aged cardiac tissue is used to identify the specific contributions of extracellular matrix ligands and mechanics for fibroblast aging.

Avery Rui Sun
Md Faris H. Ramli
Jennifer L. Young
ResearchOpen Access12 Jun 2025
Nature Materials

Volume: 24, P: 1489-1501

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Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing

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