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Showing 1–9 of 9 results
Advanced filters: Author: Avinash Waghray Clear advanced filters

  • Human airway contains physiologically relevant yet rare cells, but their scarcity prevents thorough profiling and differentiation studies. Here the authors use single cell RNA sequencing to identify rare ionocytes and tuft cells, as well as a potential progenitor population with cytokine-guided differentiation into either the ionocytes or tuft cell lineage.

    • Viral S. Shah
    • Avinash Waghray
    • Alexander M. Tsankov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • Single-cell RNA sequencing analysis identifies cell types and lineages in airway epithelium, including the pulmonary ionocyte, a new cell type predominantly expressing the cystic fibrosis gene CFTR.

    • Daniel T. Montoro
    • Adam L. Haber
    • Jayaraj Rajagopal
    Research
    Nature
    Volume: 560, P: 319-324

  • Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradation pathways and RNAi technology, to control the levels of two proteins and validate its application in stem cells.

    • Ran Brosh
    • Iryna Hrynyk
    • Ihor R. Lemischka
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • A set of ready-to-use tools for profiling fresh and frozen clinical tumor samples using scRNA-Seq and snRNA-Seq facilitates the implementation of single-cell technologies in clinical settings and the construction of single-cell tumor atlases.

    • Michal Slyper
    • Caroline B. M. Porter
    • Aviv Regev
    ResearchOpen Access
    Nature Medicine
    Volume: 26, P: 792-802

  • The generation of induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders promises to help the basic understanding of complex diseases and the development of therapeutics. Here iPSCs have been generated from patients with LEOPARD syndrome, a developmental disorder with pleiomorphic effects on several tissues and organs. The iPSCs are characterized and the phenotype of cardiomyocytes derived from these cells is investigated.

    • Xonia Carvajal-Vergara
    • Ana Sevilla
    • Ihor R. Lemischka
    Research
    Nature
    Volume: 465, P: 808-812