Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–12 of 12 results
Advanced filters: Author: Avishek Adhikari Clear advanced filters

  • Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain pathway needed for agency and activating one that promotes habit.

    • Jacqueline R. Giovanniello
    • Natalie Paredes
    • Kate M. Wassum
    Research
    Nature
    Volume: 640, P: 722-731

  • Activation of the ventral medial prefrontal cortex–basomedial amygdala pathway is shown to suppress anxiety and fear-related freezing in mice, thus identifying the basomedial amygdala (and not intercalated cells, as posited by earlier models) as a novel target of top-down control.

    • Avishek Adhikari
    • Talia N. Lerner
    • Karl Deisseroth
    Research
    Nature
    Volume: 527, P: 179-185

  • Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kimet al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible.

    • Christina K. Kim
    • Avishek Adhikari
    • Karl Deisseroth
    Reviews
    Nature Reviews Neuroscience
    Volume: 18, P: 222-235

  • High-speed tracking of effortful responses and neuronal activity in rats during a forced swim test identifies medial prefrontal cortex (mPFC) neurons that respond during escape-related swimming but not normal locomotion, and optogenetics shows that mPFC neurons projecting to the brainstem dorsal raphe nucleus, which is implicated in depression, modulate this behavioural response to challenge

    • Melissa R. Warden
    • Aslihan Selimbeyoglu
    • Karl Deisseroth
    Research
    Nature
    Volume: 492, P: 428-432

  • Neurostimulation has been proposed as a potential approach for treatment-resistant PTSD. Here in a pilot study the authors show that amygdala theta activity is heightened during aversive and symptomatic experiences in patients with treatment-resistant post-traumatic stress disorder, and reduced following significant clinical improvement associated with closed-loop stimulation.

    • Jay L. Gill
    • Julia A. Schneiders
    • Jean-Philippe Langevin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Periaqueductal gray (PAG) inputs control hunting, but foraging-inducing PAG cells were unidentified. Here, authors show that in mice activity in the projection of vgat PAG cells to the zona incerta is sufficient and necessary for food-seeking.

    • Fernando M. C. V. Reis
    • Sandra Maesta-Pereira
    • Avishek Adhikari
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Torpor is a state of reduced metabolism and body temperature that conserves energy when food is scarce. Here the authors show that estrogen-sensitive neurons in the hypothalamus regulate torpor in mice, maintaining torpor in both sexes but initiating torpor and regulating core temperature differentially across sex.

    • Zhi Zhang
    • Fernando M. C. V. Reis
    • Stephanie M. Correa
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Specific manipulation of midbrain dopamine neurons in freely moving rodents shows that their inhibition or excitation immediately modulates depression-like phenotypes that are induced by chronic mild stress, and that their activation alters the neural encoding of depression-related behaviours in the nucleus accumbens.

    • Kay M. Tye
    • Julie J. Mirzabekov
    • Karl Deisseroth
    Research
    Nature
    Volume: 493, P: 537-541