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Advanced filters: Author: Axel Choidas Clear advanced filters

Small-molecule inhibitors of human mitochondrial DNA transcription

Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.

Nina A. Bonekamp
Bradley Peter
Nils-Göran Larsson
Research16 Dec 2020
Nature

Volume: 588, P: 712-716
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer (NK) cell rejection of metastatic tumours; a small molecule TAM kinase inhibitor is shown to enhance the anti-metastatic NK cell activity.

Magdalena Paolino
Axel Choidas
Josef M. Penninger
Research19 Feb 2014
Nature

Volume: 507, P: 508-512
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia

Patricia Johansson
Ludger Klein-Hitpass
Jan Dürig
ResearchOpen Access19 Jan 2018
Blood Cancer Journal

Volume: 8, P: 1-16