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Showing 1–14 of 14 results
Advanced filters: Author: Axel Nimmerjahn Clear advanced filters

  • A miniature epifluorescence microscope that can be carried by a freely-moving adult mouse allows cellular-level imaging of neuronal spiking or measurement of microcirculation during normal behavioral activities.

    • Benjamin A Flusberg
    • Axel Nimmerjahn
    • Mark J Schnitzer
    Research
    Nature Methods
    Volume: 5, P: 935-938

  • Fluorescence imaging of the spinal cord poses challenges, including depth of imaging. Here the authors describe a custom microscope and chronically implanted microprism that enables multicolor translaminar imaging of sensory and motor evoked activity in behaving mice, and show that spinal astrocytes show sensorimotor program-dependent calcium excitation.

    • Pavel Shekhtmeyster
    • Erin M. Carey
    • Axel Nimmerjahn
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Near-infrared (NIR) probes are in high demand as fluorescent tags for multicolour cellular and in vivo imaging. Here authors develop series of NIR nanobodies that bind to GFP-based biosensors, and demonstrate ratiometric deep-brain in vivo imaging of active GCaMP6f-expressing neurons.

    • Natalia V. Barykina
    • Erin M. Carey
    • Vladislav V. Verkhusha
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Imaging cellular activity in mouse spinal cord has been historically difficult. Here the authors develop cellular resolution fluorescence imaging approaches in the spinal cord of behaving mice, and report distinct activity patterns of neurons and astrocytes in response to different sensory inputs.

    • Kohei J. Sekiguchi
    • Pavel Shekhtmeyster
    • Axel Nimmerjahn
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Mapping a full allergen circuit from the lung to the brainstem and back, repeated exposure of mice to inhaled allergen activated the nuclei of solitary tract neurons in a mast cell-, interleukin-4- and vagal nerve-dependent manner.

    • Yujuan Su
    • Jinhao Xu
    • Xin Sun
    ResearchOpen Access
    Nature
    Volume: 631, P: 601-609

  • How microglia sense amyloid plaques in Alzheimer’s disease has remained mysterious. Lemke and colleagues report that TAM receptor kinases are absolutely required for normal microglial recognition of, response to and phagocytosis of Aβ plaques. Surprisingly, TAM-mediated microglial phagocytosis of Aβ material does not constrain, but rather promotes, the formation of dense-core plaques.

    • Youtong Huang
    • Kaisa E. Happonen
    • Greg Lemke
    Research
    Nature Immunology
    Volume: 22, P: 586-594

  • An integrated, miniature (1.9 g) fluorescence microscope containing light source, optics and sensor allows high-speed, wide field of view imaging of calcium spiking in hundreds of neurons in freely moving mice. The mass-producible portable microscope is also useful for a variety of fluorescence assays for which size, cost and portability can be concerns.

    • Kunal K Ghosh
    • Laurie D Burns
    • Mark J Schnitzer
    Research
    Nature Methods
    Volume: 8, P: 871-878

  • Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.

    • Lawrence Fourgeaud
    • Paqui G. Través
    • Greg Lemke
    Research
    Nature
    Volume: 532, P: 240-244