Thymoproteasomes expressed in cortical thymic epithelial cells are essential for the generation of CD8+ T cells, but the mechanism requires further exploration. By engineering a mouse strain ectopically expressing thymoproteasomes in various antigen-presenting cells including medullary TECs, the authors identify that thymoproteasomes specifically expressed in cortical TECs but not hematopoietic cells facilitate positive selection of CD8+ T cells.
- Mami Matsuda-Lennikov
- Jamie-Jean De La Torre
- Yousuke Takahama
