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Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

Till Schwämmle
Gemma Noviello
Edda G. Schulz
ResearchOpen Access06 Oct 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2465-2475
Author Correction: Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation

Uirá Souto Melo
Jerome Jatzlau
Malte Spielmann
Amendments and CorrectionsOpen Access09 Oct 2023
Nature Communications

Volume: 14, P: 1
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation

Heterotopic ossification is a disorder characterized by the transformation of soft tissue to bone. In this study the authors report heterotopic ossification in a child caused by enhancer hijacking at the ARHGAP36 gene, the ectopic activation by an enhancer that it not its own.

Uirá Souto Melo
Jerome Jatzlau
Malte Spielmann
ResearchOpen Access11 Apr 2023
Nature Communications

Volume: 14, P: 1-13

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