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Showing 1–4 of 4 results
Advanced filters: Author: Béatrice Kunz Clear advanced filters

  • The study identifies a cellular defense pathway, named LORD (Lipid Oxygen Radical Defense), that protects cells from lipid oxidation and ferroptosis through an epigenetically regulated program linking oxidative stress sensing to redox homeostasis and cell survival.

    • Francisco S. Mesquita
    • Laurence Abrami
    • F. Gisou van der Goot
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-22

  • The fusogenic activity of SARS-CoV-2 Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Here, Mesquita and Abrami et al. show that SARS-CoV-2 infection and colitis in mice induce a damage response resulting in an altered version of the ZDHHC20 enzyme that is more abundant and significantly more efficient at attaching fatty acids to viral Spike.

    • Francisco S. Mesquita
    • Laurence Abrami
    • F. Gisou van der Goot
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediating its oligomerisation, turnover, and localisation.

    • Patrick A. Sandoz
    • Robin A. Denhardt-Eriksson
    • F. Gisou van der Goot
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Hyaline fibromatosis syndrome (HFS) is a hereditary disease characterized by nodular cutaneous lesions and joint pain. Here Bürgiet al. show that CMG2/ANTXR2 regulates collagen VI abundance, with loss-of-function mutations promoting collagen VI accumulation in HFS nodules and myometrial collagen deposition and sterility in mice, which can be rescued by depleting collagen VI.

    • Jérôme Bürgi
    • Béatrice Kunz
    • F. Gisou van der Goot
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10