Nature Search

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

4D-scanning transmission electron microscopy uses diffractive imaging for structural studies. Here, authors study single particle cryo-EM protein samples at up to 5.8 Å resolution, using 4D-STEM and ptychography data processing.

Berk Küçükoğlu
Inayathulla Mohammed
Henning Stahlberg
ResearchOpen Access14 Sept 2024
Nature Communications

Volume: 15, P: 1-10
Half a century of rising extinction risk of coral reef sharks and rays

Sharks and rays are vital coral reef species. This study shows that nearly two thirds (59%) of the 134 coral-reef associated species are threatened with extinction. The main cause of their decline is found to be overfishing, both targeted and unintentional, and extinction risk is greater for larger species found in nations with higher fishing pressure and weaker governance.

C. Samantha Sherman
Colin A. Simpfendorfer
Nicholas K. Dulvy
ResearchOpen Access17 Jan 2023
Nature Communications

Volume: 14, P: 1-11
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria

Global antibiotic scarcity looms owing to bacterial resistance. Now the discovery of a class of allosteric inhibitors targeting DNA gyrase—essential for bacteria—yields a compound LEI-800 that exhibits activity against fluoroquinolone-resistant E. coli. The compound’s unique mode of action, revealed through cryo-EM, makes it a promising candidate for countering bacterial resistance.

Alexander T. Bakker
Ioli Kotsogianni
Mario van der Stelt
ResearchOpen Access19 Jun 2024
Nature Chemistry

Volume: 16, P: 1462-1472
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment

Lindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands.

Dominik Lindenhofer
Simon Haendeler
Jürgen A. Knoblich
ResearchOpen Access07 May 2024
Nature Cell Biology

Volume: 26, P: 710-718
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation

Aortic aneurysms have a heritable basis. Here, the authors report that a selenoprotein deficiency disorder due to mutations in SECISBP2, causes oxidative stress-mediated aortic cell death, predisposing to thoracic aortic aneurysm formation.

Erik Schoenmakers
Federica Marelli
Krishna Chatterjee
ResearchOpen Access02 Dec 2023
Nature Communications

Volume: 14, P: 1-14
A haem-sequestering plant peptide promotes iron uptake in symbiotic bacteria

A plant peptide binds to haem, thereby reducing the availability of haem and inducing an iron-starvation response in rhizobia that results in iron import for nitrogenase activity.

Siva Sankari
Vignesh M. P. Babu
Graham C. Walker
Research11 Aug 2022
Nature Microbiology

Volume: 7, P: 1453-1465
Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography

Cryo-electron tomography reveals unanticipated features of Bdellovibro predation of Gram-negative bacteria.

Mohammed Kaplan
Yi-Wei Chang
Grant J. Jensen
Research22 Jun 2023
Nature Microbiology

Volume: 8, P: 1267-1279
Single-cell dissection of aggression in honeybee colonies

The genetic basis of collective behaviour is complex. Single-cell transcriptomics of honeybee brains and gene regulatory network analysis showed differences in brain gene regulation and gene regulatory network plasticity between aggressive soldiers and non-aggressive foragers.

Ian M. Traniello
Syed Abbas Bukhari
Gene E. Robinson
Research01 Jun 2023
Nature Ecology & Evolution

Volume: 7, P: 1232-1244
Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production

There are a lack of eukaryotic biosensors specific for branched-chain amino acid (BCAA)-derived products. Here the authors report a genetically encoded biosensor for BCAA metabolism based on the Leu3p transcriptional regulator; they use this to monitor yeast production of isobutanol and isopentanol.

Yanfei Zhang
Jeremy D. Cortez
José L. Avalos
ResearchOpen Access12 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Improving the stimulated Raman adiabatic passage efficiency for ultracold ⁶Li⁴⁰K ground state molecules

Efficient creation of ultracold polar molecules is crucial for applications in quantum simulation, computation, and precision measurement. Here, the authors demonstrate the improvement of STIRAP efficiency for the ground state transfer of ⁶Li⁴⁰K molecules to over 90% by suppressing the fast laser amplitude/phase noise and operating at a single-photon detuning comparable to the intermediate state scattering rate.

Anbang Yang
Canming He
Kai Dieckmann
ResearchOpen Access10 Oct 2025
Communications Physics

Volume: 8, P: 1-8
Revisiting the role of interleukin-8 in chronic lymphocytic leukemia

Denise Risnik
Enrique Podaza
Mirta Giordano
ResearchOpen Access16 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Jane Tian
Ana Maria Avalos
Anthony J Coyle
Research08 Apr 2007
Nature Immunology

Volume: 8, P: 487-496
Role for TNF in atherosclerosis? Lessons from autoimmune disease

Pathways associated with inflammation are thought to account for increased vascular risk in patients with chronic inflammatory diseases. This Review summarizes key epidemiologic, physiologic and model data that implicate involvement of tumor necrosis factor, a pivotal cytokine in the inflammatory cascade, in atherosclerosis.

Gayle E. McKellar
David W. McCarey
Iain B. McInnes
Reviews07 May 2009
Nature Reviews Cardiology

Volume: 6, P: 410-417
Prosocial correlates of transformative experiences at secular multi-day mass gatherings

Mass gatherings may elicit experiences of profound personal change. Here the authors show across six field sites that reporting of transformative experiences at mass gatherings are common, increase over time, and predict lasting increases in participants’ circle of moral regard.

Daniel A. Yudkin
Annayah M. B. Prosser
M. J. Crockett
ResearchOpen Access27 May 2022
Nature Communications

Volume: 13, P: 1-13
Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

Maria Carolina Dalmasso
Luis Ignacio Brusco
Alfredo Ramirez
ResearchOpen Access31 Jan 2019
Translational Psychiatry

Volume: 9, P: 1-6
HyphaTracker: An ImageJ toolbox for time-resolved analysis of spore germination in filamentous fungi

Michael Brunk
Sebastian Sputh
Ulrich Terpitz
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Ensemble cryo-EM elucidates the mechanism of translation fidelity

Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

Anna B. Loveland
Gabriel Demo
Andrei A. Korostelev
Research24 May 2017
Nature

Volume: 546, P: 113-117
Successful engraftment of allogeneic PBSC after conditioning with busulfan alone

I Majolino
AM Cavallaro
R Scime′
Research01 Mar 1997
Bone Marrow Transplantation

Volume: 19, P: 621-623
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

E Lara
A Mai
M F Fraga
Research08 Dec 2008
Oncogene

Volume: 28, P: 781-791
Structure of the cross-β spine of amyloid-like fibrils

Rebecca Nelson
Michael R. Sawaya
David Eisenberg
Research09 Jun 2005
Nature

Volume: 435, P: 773-778
Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase

J F Porter
S Shen
D T Denhardt
ResearchOpen Access20 Jan 2004
British Journal of Cancer

Volume: 90, P: 463-470
Optically Active Polysilanes. Ten Years of Progress and New Polymer Twist for Nanoscience and Nanotechnology

Michiya Fujiki
Julian Robert Koe
Junji Watanabe
Reviews01 Apr 2003
Polymer Journal

Volume: 35, P: 297-344
Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1α) gene

X Xin
K Nakamura
A Iwamoto
Research27 Jun 2001
Genes & Immunity

Volume: 2, P: 156-158
Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s disease

Justin Moore
Timothy Wu
Juan Botas
ResearchOpen Access11 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-13
High-dose etoposide with granulocyte colony-stimulating factor for mobilization of peripheral blood progenitor cells: efficacy and toxicity at three dose levels

EJ Kanfer
D McGuigan
ES Newlands
Research01 Oct 1998
British Journal of Cancer

Volume: 78, P: 928-932
Control of myeloid differentiation and survival by Stats

Thomas E Smithgall
Scott D Briggs
Matthew B Wilson
Research25 May 2000
Oncogene

Volume: 19, P: 2612-2618
Interactions between the AraC/XylS-like transcriptional activator InvF of Salmonella Typhimurium, the RNA polymerase alpha subunit and the chaperone SicA

Daniel Cortés-Avalos
André Borges Farias
J. Antonio Ibarra
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
The association between intrauterine exposure to opioids, tobacco, alcohol, and cannabis and length of birth hospitalization among neonates without NOWS

Steven J. Ondersma
Amii M. Kress
Barry Lester
Research09 May 2023
Journal of Perinatology

Volume: 43, P: 949-951
CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context

Andrea S. Guzman
Maria P. Avalos
Liliana M. Cancela
ResearchOpen Access21 Jun 2021
Scientific Reports

Volume: 11, P: 1-18
High-dose busulfan, cyclophosphamide, and etoposide does not improve outcome of allogeneic stem cell transplantation compared to BuCy2 in patients with acute myeloid leukemia

S S Farag
B J Bolwell
E Copelan
Research14 Feb 2005
Bone Marrow Transplantation

Volume: 35, P: 653-661
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort

Michael S. Bloom
Sudhi Upadhyaya
Lynne M. Smith
ResearchOpen Access15 Feb 2025
Journal of Exposure Science & Environmental Epidemiology

Volume: 35, P: 992-1002
Agonist-Promoted Down-Regulation and Functional Desensitization in Two Naturally Occurring Variants of the Human Serotonin_1A Receptor

Alessandro Rotondo
David A Nielsen
David Goldman
Research01 Jul 1997
Neuropsychopharmacology

Volume: 17, P: 18-26
Radiation-free regimens result in similar outcomes of allogeneic hematopoietic progenitor cell transplantation in patients aged ≥50 years compared to younger adults with low-risk disease

S S Farag
P J Elder
E Copelan
Research28 Jan 2003
Bone Marrow Transplantation

Volume: 31, P: 87-93
Etoposide plus G-CSF priming compared with G-CSF alone in patients with lymphoma improves mobilization without an increased risk of secondary myelodysplasia and leukemia

A Mahindra
B J Bolwell
E Copelan
Research04 Apr 2011
Bone Marrow Transplantation

Volume: 47, P: 231-235
Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis

Perrine Soret
Louise-Eva Vandenborght
Dominique Turck
ResearchOpen Access27 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium

Kimberly McKee
Christine M. Bassis
Lynne M. Smith
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-19
Therapy-related myelodysplasia and leukemia occur infrequently following VP-16 priming and autotransplantation without total body irradiation

E Copelan
S Hoshaw-Woodard
B Avalos
Research24 May 2004
Bone Marrow Transplantation

Volume: 34, P: 85-87
Autotransplantation following busulfan, etoposide and cyclophosphamide in patients with non-Hodgkin's lymphoma

EA Copelan
SL Penza
BJ Bolwell
Research19 Jun 2000
Bone Marrow Transplantation

Volume: 25, P: 1243-1248
Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables

Pablo Delgado-Wicke
Sara Fernández de Córdoba-Oñate
Isabel Iturrate
ResearchOpen Access05 Sept 2024
Scientific Reports

Volume: 14, P: 1-10
A review of the genetic and long-term effects of G-CSF injections in healthy donors: a reassuring lack of evidence for the development of haematological malignancies

B E Shaw
D L Confer
M A Pulsipher
Reviews19 Jan 2015
Bone Marrow Transplantation

Volume: 50, P: 334-340
The arthropod, but not the vertebrate host or its environment, dictates bacterial community composition of fleas and ticks

Hadas Hawlena
Evelyn Rynkiewicz
Keith Clay
Research28 Jun 2012
The ISME Journal

Volume: 7, P: 221-223
Label-free enumeration, collection and downstream cytological and cytogenetic analysis of circulating tumor cells

Manjima Dhar
Edward Pao
Dino Di Carlo
ResearchOpen Access14 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1

D O Croci
P E Morande
M Giordano
Correspondence07 Nov 2012
Leukemia

Volume: 27, P: 1413-1416
Cross-cultural data on romantic love and mate preferences from 117,293 participants across 175 countries

Marta Kowal
Piotr Sorokowski
Filipe Prazeres
ResearchOpen Access01 Jul 2025
Scientific Data

Volume: 12, P: 1-12
Mifepristone-inducible transgene expression in neural progenitor cells in vitro and in vivo

B E Hjelm
C Grunseich
T M Pierson
Research10 Feb 2016
Gene Therapy

Volume: 23, P: 424-437
Diffuse alveolar hemorrhage following gemtuzumab ozogamicin

T S Lin
S L Penza
E A Copelan
Correspondence28 Feb 2005
Bone Marrow Transplantation

Volume: 35, P: 823-824
Hematopoietic cell transplantation in MDS: undervalued and underutilized

M R Grunwald
B R Avalos
E A Copelan
Comments & Opinion20 Jun 2016
Bone Marrow Transplantation

Volume: 51, P: 1069-1070

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