Nature Search

The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease

Patients with Parkinson’s disease treated with fetal tissue are assessed 3 years after surgery.

Roger A. Barker
Nicholas P. Lao-Kaim
Gesine Paul
ResearchOpen Access02 May 2025
Nature Biotechnology

Volume: 44, P: 70-78
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

Paola Piccini
David J. Brooks
Olle Lindvall
Research01 Dec 1999
Nature Neuroscience

Volume: 2, P: 1137-1140
Rewiring the Parkinsonian brain

The demonstration that transplanted embryonic stem cells differentiate into functional dopamine neurons and provide stable functional recovery in a rodent model of Parkinson disease moves the field a step closer to clinical applications of embryonic stem cells.

Rosemary A. Fricker-Gates
Stephen B. Dunnett
News & Views01 Feb 2002
Nature Medicine

Volume: 8, P: 105-106
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and identify perivascular-like cells.

Katarína Tiklová
Sara Nolbrant
Malin Parmar
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-11
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons.

Katarína Tiklová
Åsa K. Björklund
Thomas Perlmann
ResearchOpen Access04 Feb 2019
Nature Communications

Volume: 10, P: 1-12
Meta-analysis reveals that phenotypic plasticity and divergent selection promote reproductive isolation during incipient speciation

The authors examine factors affecting reproductive isolation in the early stages of speciation by collating data from 34 experimental speciation studies in 15 species ranging from yeast to vertebrates. They show that both phenotypic plasticity and divergent selection pressures accelerate the emergence of reproductive isolation, with plasticity promoting pre-mating isolation barriers in particular.

Benjamin J. M. Jarrett
Philip A. Downing
Erik I. Svensson
ResearchOpen Access07 May 2025
Nature Ecology & Evolution

Volume: 9, P: 833-844
Emittance preservation in a plasma-wakefield accelerator

High beam quality is key for particle-accelerator applications in high-energy physics and photon science. Here, authors demonstrate gigavolt-per meter acceleration of electron bunches in a plasma-wakefield accelerator with no degradation of emittance, while also preserving charge and energy spread.

C. A. Lindstrøm
J. Beinortaitė
J. Osterhoff
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-10
Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder

Patients with diabetes have an increased susceptibility to infections. Here the authors show that high glucose impairs innate immunity through reduced levels of the antimicrobial peptide psoriasin and impaired epithelial barrier function, resulting in an increased risk of urinary tract infection.

Soumitra Mohanty
Witchuda Kamolvit
Annelie Brauner
ResearchOpen Access20 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

A spatial transcriptomics and single-cell multiomics study performed on mouse brain tissue. Here, authors show region-specific spaceflight-induced alterations in processes of neurogenesis, synaptogenesis and synaptic transmission.

Yuvarani Masarapu
Egle Cekanaviciute
Stefania Giacomello
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-14
Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause

Sequence analysis identifies gain-of-function somatic mutations in GNA11 or GNAQ in CTNNB1-mutant aldosterone-producing adenomas. Most patients with these mutations presented during puberty, pregnancy or menopause, with elevated LHCGR expression.

Junhua Zhou
Elena A. B. Azizan
Morris J. Brown
Research12 Aug 2021
Nature Genetics

Volume: 53, P: 1360-1372
Functional reactivation of the deafferented neostriatum by nigral transplants

A. Björklund
U. Stenevi
S. D. Iversen
Research05 Feb 1981
Nature

Volume: 289, P: 497-499
Cross-species neural grafting in a rat model of Parkinson's disease

Anders Björklund
Ulf Stenevi
Fred H. Gage
Research12 Aug 1982
Nature

Volume: 298, P: 652-654
Fennoscandian tree-ring anatomy shows a warmer modern than medieval climate

Annually resolved Fennoscandian tree-ring anatomy records show that the climate of the current industrial era is substantially warmer than that of the medieval period.

Jesper Björklund
Kristina Seftigen
Georg von Arx
Research02 Aug 2023
Nature

Volume: 620, P: 97-103
Dyskinesias following neural transplantation in Parkinson's disease

Peter Hagell
Paola Piccini
Olle Lindvall
Research03 Jun 2002
Nature Neuroscience

Volume: 5, P: 627-628
Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions

Walter C. Low
Peter R. Lewis
Ulf Stenevi
Research18 Nov 1982
Nature

Volume: 300, P: 260-262
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Jia-Yi Li
Elisabet Englund
Patrik Brundin
Research06 Apr 2008
Nature Medicine

Volume: 14, P: 501-503
Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants

Transcription factor DREB2A interacts with Med25 to regulate stress responses. Here, the authors show that DREB2A uses splicing and proline-isomerization for this regulation and that proline cis-trans switching introduces structural frustration facilitating regulator exchange.

Frederik Friis Theisen
Andreas Prestel
Karen Skriver
ResearchOpen Access18 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Author Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons

Erik Södersten
Konstantinos Toskas
Johan Holmberg
Amendments and CorrectionsOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.

Katy Börner
Philip D. Blood
Bruce W. Herr II
ResearchOpen Access13 Mar 2025
Nature Methods

Volume: 22, P: 845-860
Author Correction: A comprehensive human embryo reference tool using single-cell RNA-sequencing data

Cheng Zhao
Alvaro Plaza Reyes
Fredrik Lanner
Amendments and CorrectionsOpen Access24 Jan 2025
Nature Methods

Volume: 22, P: 636
Cell therapy in Parkinson's disease – stop or go?

Stephen B. Dunnett
Anders Björklund
Olle Lindvall
Reviews01 May 2001
Nature Reviews Neuroscience

Volume: 2, P: 365-369
Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction

Artificial intelligence prediction accuracy can be reduced with new data. Here, the authors utilise conformal prediction to reduce incorrect predictions in histopathological analysis of prostate cancer biopsies.

Henrik Olsson
Kimmo Kartasalo
Martin Eklund
ResearchOpen Access15 Dec 2022
Nature Communications

Volume: 13, P: 1-10
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putatively different functions.

Michael Bartoschek
Nikolay Oskolkov
Kristian Pietras
ResearchOpen Access04 Dec 2018
Nature Communications

Volume: 9, P: 1-13
A comprehensive human embryo reference tool using single-cell RNA-sequencing data

This resource integrates different human embryo datasets to create a transcriptional reference map of human embryonic development from zygote to gastrula.

Cheng Zhao
Alvaro Plaza Reyes
Fredrik Lanner
ResearchOpen Access14 Nov 2024
Nature Methods

Volume: 22, P: 193-206
A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons

The limited size of some neuronal types and their entangled environment renders it difficult to study their transcription regulation. Here the authors present a comparative analysis of histone modifications and transcription in dopaminergic and serotonergic neurons and embryonic neural progenitors.

Erik Södersten
Konstantinos Toskas
Johan Holmberg
ResearchOpen Access26 Mar 2018
Nature Communications

Volume: 9, P: 1-16
Activating mutations in CTNNB1 in aldosterone producing adenomas

Tobias Åkerström
Rajani Maharjan
Peyman Björklund
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging

Organ Mapping Antibody Panels are a community-led initiative to create standardized antibody panels for multiplexed spatial imaging.

Ellen M. Quardokus
Diane C. Saunders
Andrea J. Radtke
ResearchOpen Access19 Jul 2023
Nature Methods

Volume: 20, P: 1174-1178
MALNC: a new mutant NPM1/IDH2^R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response

Elisabetta Cozzi
Anne Neddermeyer
Sören Lehmann
ResearchOpen Access23 Aug 2025
Cancer Gene Therapy

Volume: 32, P: 1191-1205
Adaptive responses of animals to climate change are most likely insufficient

It is unclear whether species’ responses to climate change tend to be adaptive or sufficient to keep up with climate change. Here, Radchuk et al. perform a meta-analysis showing that in birds phenology has advanced adaptively in some species, though not all the way to the new optima.

Viktoriia Radchuk
Thomas Reed
Stephanie Kramer-Schadt
ResearchOpen Access23 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis

Grieger, Takele, Vesco, et al. perform a systematic review and meta-analysis of gestational weight gain interventions. Findings indicate lifestyle interventions that reduce excessive gestational weight gain provide greater benefits for women with a normal BMI and higher HDL cholesterol levels at the initiation of interventions.

Jessica A. Grieger
Wubet Worku Takele
Siew Lim
ResearchOpen Access24 Oct 2025
Communications Medicine

Volume: 5, P: 1-13
The heterogeneity of human CD127⁺ innate lymphoid cells revealed by single-cell RNA sequencing

Several populations of innate lymphoid cells have been identified by their cytokine and transcription factor expression. Mjösberg and colleagues report considerable heterogeneity within human tonsil innate lymphoid cell subpopulations, as revealed by single-cell RNA-sequencing profiling.

Åsa K Björklund
Marianne Forkel
Jenny Mjösberg
Research15 Feb 2016
Nature Immunology

Volume: 17, P: 451-460
Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy

Attilio Iemolo
Maria De Risi
Elvira De Leonibus
ResearchOpen Access16 Jun 2023
npj Parkinson's Disease

Volume: 9, P: 1-15
Conventional twin studies overestimate the environmental differences between families relevant to educational attainment

Tobias Wolfram
Damien Morris
ResearchOpen Access17 Jul 2023
npj Science of Learning

Volume: 8, P: 1-12
Author Correction: Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Katarína Tiklová
Sara Nolbrant
Malin Parmar
Amendments and CorrectionsOpen Access15 Jul 2020
Nature Communications

Volume: 11, P: 1
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Walerych et al. show that p53 missense mutants upregulate the proteasome and increase breast cancer cell resistance to proteasome inhibitors. Combined inhibition of p53 mutants and the proteasome leads to increased therapeutic efficacy.

Dawid Walerych
Kamil Lisek
Giannino Del Sal
Research27 Jun 2016
Nature Cell Biology

Volume: 18, P: 897-909
Lung Trauma From Five Moderately Large Manual Inflations Immediately After Surfactant Instillation in Newborn Immature Lambs † 1678

J Ingimarsson
L J Björklund
O Werner
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 286
Preceding surfactant treatment does not protect against lung volutrauma at birth † 1518

J Ingimarsson
L J Björklund
O Werner
Research01 Apr 1997
Pediatric Research

Volume: 41, P: 255
Acetylcholine revisited

Anders Björklund
Stephen B. Dunnett
News & Views08 Jun 1995
Nature

Volume: 375, P: 446
Severe Respiratory Insufficiency in Near Term Infants - What's the Use of ECMO?

D Ley
L J Björklund
N W Svenningsen
Research01 Jun 1999
Pediatric Research

Volume: 45, P: 889
LUNG INJURY CAUSED BY NEONATAL RESUSCITATION OF IMMATURE LAMBS - RELATION TO VOLUME OF LUNG INFLATIONS. † 1942

Lars J Björklund
Tore Curstedt
Olof Werner
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 326
Urine D-Arabinitol/L-Arabinitol (DA/LA) Ratio in the Diagnosis of Invasive Candidiasis in Newborn Infants

Gudrun Sigmundsdóttir
Lars J Björklund
Christina Pehrson
Research01 Jun 1999
Pediatric Research

Volume: 45, P: 889
Static Pressure-Volume (P-V) Loops of the Respiratory System in Surfactant-Treated Immature Lambs in vivo - Effect of Positive End-Expiratory Pressure (PEEP) 1679

Jonas Ingimarsson
Lars J Björklund
Olof Werner
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 286
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

A systematic review of evidence, across the key pillars of prevention, diagnosis, treatment and prognosis, outlines milestones that need to be met to enable the broad clinical implementation of precision medicine in diabetes care.

Deirdre K. Tobias
Jordi Merino
Paul W. Franks
Reviews05 Oct 2023
Nature Medicine

Volume: 29, P: 2438-2457
Neurophysiology/pharmacology of erection

K-E Andersson
Research26 Jul 2001
International Journal of Impotence Research

Volume: 13, P: S8-S17
Recent introgression between Taiga Bean Goose and Tundra Bean Goose results in a largely homogeneous landscape of genetic differentiation

Jente Ottenburghs
Johanna Honka
Hans Ellegren
ResearchOpen Access26 May 2020
Heredity

Volume: 125, P: 73-84
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Michael A van Es
Paul WJ van Vught
Leonard H van den Berg
Research16 Dec 2007
Nature Genetics

Volume: 40, P: 29-31
Comparative analysis of the multivariate genetic architecture of morphological traits in three species of Gomphocerine grasshoppers

Anasuya Chakrabarty
Holger Schielzeth
Research24 Oct 2019
Heredity

Volume: 124, P: 367-382
CYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: results of a meta-analysis in 2063 patients

J-L Pujol
O Molinier
J Grenier
ResearchOpen Access04 May 2004
British Journal of Cancer

Volume: 90, P: 2097-2105
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors

Richard Lifton and colleagues identify a recurrent activating mutation in PRKACA, which encodes the catalytic subunit of protein kinase A, in cortisol-producing adrenal tumors. They further show that the mutation results in loss of binding by the regulatory subunit PRKAR1A, leading to increased phosphorylation of downstream targets.

Gerald Goh
Ute I Scholl
Richard P Lifton
Research20 Apr 2014
Nature Genetics

Volume: 46, P: 613-617
Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

Richard Lifton and colleagues identify somatic and germline mutations in the CACNA1D calcium channel gene in aldosterone-producing adenomas and primary aldosteronism. Their functional studies show that these mutations result in channel activation at more hyperpolarized membrane potentials, implicating increased Ca²⁺ influx in disease pathogenesis.

Ute I Scholl
Gerald Goh
Richard P Lifton
Research04 Aug 2013
Nature Genetics

Volume: 45, P: 1050-1054

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