Nature Search

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

Here, the authors isolate and characterize a bispecific monomeric nanobody that induces dimerization of SARS-CoV-2 spike trimers, neutralizes variants of concerns as well as SARS-CoV, and inhibits SARS-CoV-2 infection in mice.

Leo Hanke
Hrishikesh Das
Gerald M. McInerney
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-11
A Photometric Method for Avian Liver Xanthine Dehydrogenase

HEINZ G. SCHWARTZ
GERALD LITWACK
Research12 Oct 1957
Nature

Volume: 180, P: 761-763
High-performance Propane Fuel Cells

W. T. GRUBB
Research15 Feb 1964
Nature

Volume: 201, P: 699-700
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis

Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Here, Faust et al. find that healthy human synovial fibroblasts under the influence of adjacent adipocytes have altered lipid metabolism driven by cortisol signaling. Both adipocytes and these characteristics are lost in inflammatory arthritis.

Heather J. Faust
Tan-Yun Cheng
Michael B. Brenner
ResearchOpen Access14 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Possible relationship of morphogenesis in pathogenic fungus, Histoplasma capsulatum, to heat shock response

Alan M. Lambowitz
George S. Kobayashi
Gerald Medoff
Research30 Jun 1983
Nature

Volume: 303, P: 806-808
Implementation of a national AI technology program on cardiovascular outcomes and the health system

National implementation of a computed tomographic angiography and AI-diagnostic tool, CT-derived fractional flow reserve (FFR-CT), did not provide significant benefits in reducing mortality but led to fewer invasive coronary angiograms and downstream cardiac tests.

Timothy A. Fairbairn
Liam Mullen
Jonathan Weir-McCalL
ResearchOpen Access04 Apr 2025
Nature Medicine

Volume: 31, P: 1903-1910
[Letters to Editor]

GERALD B. FRANCIS
Research08 Aug 1878
Nature

Volume: 18, P: 383
Effect of vorticity pollution by motor vehicles on tornadoes

JOHN D. ISAACS
JAMES W. STORK
GERALD L. WICK
Research24 Jan 1975
Nature

Volume: 253, P: 254-255
Bacterial Oxidation of Lactose and Melibiose

B. P. EDDY
Research29 Mar 1958
Nature

Volume: 181, P: 904-905
Die-back of Pistia stratiotes on Volta Lake, Ghana

D. U. U. OKALI
J. B. HALL
Research29 Mar 1974
Nature

Volume: 248, P: 452-453
Microsomal L-Gulonolactone Dehydrogenase

N. C. KAR
N. C. GHOSH
B. C. GUHA
Research02 Feb 1963
Nature

Volume: 197, P: 494-495
Role of Dendritic Cells in the Infective Colour Transformation of Guinea Pig's Skin

R. E. BILLINGHAM
P. B. MEDAWAR
Research12 Jul 1947
Nature

Volume: 160, P: 61-62
A small electron donor in cobalt complex electrolyte significantly improves efficiency in dye-sensitized solar cells

The electrolyte is an important component of dye-sensitized solar cells. Here, Haoet al. use an electron donor additive in the cobalt-based electrolyte, which speeds up the dye regeneration and slows down recombinations. The resulting devices are stable and more efficient than those without additive.

Yan Hao
Wenxing Yang
Gerrit Boschloo
ResearchOpen Access21 Dec 2016
Nature Communications

Volume: 7, P: 1-8
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Isolation of a Lymphoid-cell Protein with Relation to Delayed Hypersensitivity

ULF ROTHMAN
STURE LIDÉN
Research23 Oct 1965
Nature

Volume: 208, P: 389-390
Glycoproteins from Connective Tissue of Twins

S. R. SRINIVASAN
B. RADHAKRISHNAMURTHY
G. S. BERENSON
Research01 Jan 1971
Nature

Volume: 229, P: 58-59
Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

In this study, the authors investigate the dissemination and evolution of vaccination-induced antibody lineages in macaques and show that members of neutralizing lineages acquire different breadths allowing recognition of both previously encountered and not encountered viral variants.

Marco Mandolesi
Hrishikesh Das
Gunilla B. Karlsson Hedestam
ResearchOpen Access27 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Quaternary and tertiary structure of haemerythrin

KEITH B. WARD
WAYNE A. HENDRICKSON
GERALD L. KLIPPENSTEIN
Research30 Oct 1975
Nature

Volume: 257, P: 818-821
Development of Micrococcus lysodeikticus Resistant to Lysozyme

GERALD LITWACK
Research10 May 1958
Nature

Volume: 181, P: 1348-1350
Clusters of cyclones encircling Jupiter’s poles

Visible and infrared images obtained from above each pole of Jupiter by the Juno spacecraft reveal polygonal patterns of large cyclones; it is unknown how these cyclones evolved, or how they persist without merging.

A. Adriani
A. Mura
M. Amoroso
Research08 Mar 2018
Nature

Volume: 555, P: 216-219
First direct evidence of life under Antarctic shelf ice

R. B. HEYWOOD
J. J. LIGHT
Research01 Apr 1975
Nature

Volume: 254, P: 591-592
Catalytic Investigations using Galvanostatic Techniques

T. J. GRAY
R. B. ROZELLE
M. L. SOEDER
Research11 Apr 1964
Nature

Volume: 202, P: 181-182
Positive feedbacks and alternative stable states in forest leaf types

Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.

Yibiao Zou
Constantin M. Zohner
Thomas W. Crowther
ResearchOpen Access31 May 2024
Nature Communications

Volume: 15, P: 1-15
Polymorphism in Collagen Fibrils precipitated at Low pH

JONATHAN B. L. BARD
JOHN A. CHAPMAN
Research21 Sept 1968
Nature

Volume: 219, P: 1279-1280
A transcriptional hierarchy involved in mammalian cell-type specification

Calvin J. Kuo
Pamela B. Conley
Gerald R. Crabtree
Research30 Jan 1992
Nature

Volume: 355, P: 457-461
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation

Redox signal transduction from the mitochondrial matrix to the cytosol is shown to be mediated through interaction between MIC60 and Miro, the disruption of which ameliorates oxidative stress in Drosophila.

Li Li
Devon M. Conradson
Xinnan Wang
Research09 Sept 2021
Nature Metabolism

Volume: 3, P: 1242-1258
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.

Fan Zhang
Anna Helena Jonsson
Soumya Raychaudhuri
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 616-624
Antibody stabilization for thermally accelerated deep immunostaining

Thermostable antibodies called SPEARs enable rapid immunostaining with improved tissue penetration.

Hei Ming Lai
Yumi Tang
Ho Ko
ResearchOpen Access01 Sept 2022
Nature Methods

Volume: 19, P: 1137-1146
Vitamin A Inhibition of Cortisol Induction of HeLa Alkaline Phosphatase

M. J. GRIFFIN
H. R. CAMA
Research21 Nov 1970
Nature

Volume: 228, P: 762-763
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.

Leo Hanke
Laura Vidakovics Perez
Gerald M. McInerney
ResearchOpen Access04 Sept 2020
Nature Communications

Volume: 11, P: 1-9
Effect of L-Asparaginase from Aspergillus terreus on Ascites Sarcoma in the Rat

LAVINIA CARTA DE-ANGELI
F. POCCHIARI
A. PERIN
Research07 Feb 1970
Nature

Volume: 225, P: 549-550
Alginic Acid Diacetate

N. H. CHAMBERLAIN
G. E. CUNNINGHAM
J. B. SPEAKMAN
Research19 Oct 1946
Nature

Volume: 158, P: 553
One-quarter of freshwater fauna threatened with extinction

A global multi-taxon extinction risk assessment of freshwater fauna for The IUCN Red List of Threatened Species finds one-quarter of species to be at high risk of extinction.

Catherine A. Sayer
Eresha Fernando
William R. T. Darwall
ResearchOpen Access08 Jan 2025
Nature

Volume: 638, P: 138-145
Zinc Deficiency induced by Mercury in Coffea arabica

K. R. BOCK
J. B. D. ROBINSON
G. T. CHAMBERLAIN
Research06 Dec 1958
Nature

Volume: 182, P: 1607-1608
DNA twisting and the effects of non-contacted bases on affinity of 434 operator for 434 represser

Gerald B. Koudelka
Paul Carlson
Research02 Jan 1992
Nature

Volume: 355, P: 89-91
A dual role for autophagy in a murine model of lung cancer

Autophagy prolongs the survival of cells in stressful conditions but its role in cancer is unclear. Here, Rao et al. show that loss of the autophagic protein Atg5 enhanced cancer incidence but impaired tumour progression in a mouse model of lung cancer.

Shuan Rao
Luigi Tortola
Josef M. Penninger
Research20 Jan 2014
Nature Communications

Volume: 5, P: 1-15
Submarine Tubes for Levelling

R. B. MONTGOMERY
Research22 Mar 1947
Nature

Volume: 159, P: 408
Pretrained transformers applied to clinical studies improve predictions of treatment efficacy and associated biomarkers

A framework for building foundation models using diverse patient data can enhance survival prediction and provide interpretable insights into treatment response. Here, the authors show that their approach outperforms existing methods while integrating generative and interpretable modules to reveal clinically relevant biological insights.

Gustavo Arango-Argoty
Elly Kipkogei
Etai Jacob
ResearchOpen Access01 Mar 2025
Nature Communications

Volume: 16, P: 1-18
LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Targeted nanodrug delivery is crucial to treat respiratory diseases, but profiling the delivery and dynamics of nanoparticles (NPs) within the lung is a challenging task. Here, the authors present LungVis 1.0, an AI-driven 3D imaging ecosystem to profile inhaled substances in distinct lung regions while uncovering the role of tissue-resident macrophages in the fate of NPs.

Lin Yang
Qiongliang Liu
Otmar Schmid
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-22
Artefactual Chromatid Aberrations in Untreated and X-ray-treated Human Lymphocytes

B. R. MIGEON
T. MERZ
Research26 Sept 1964
Nature

Volume: 203, P: 1395-1396
Radar evidence of an accessible cave conduit on the Moon below the Mare Tranquillitatis pit

A void tens of metres in size below the Mare Tranquillitatis pit on the Moon is revealed by radar images from the Lunar Reconnaissance Orbiter. This finding implies that lava tubes or conduits are possibly common below lunar maria.

Leonardo Carrer
Riccardo Pozzobon
Lorenzo Bruzzone
Research15 Jul 2024
Nature Astronomy

Volume: 8, P: 1119-1126
Diatom mystery

THOMAS S. MCCONNELL
GERALD T. ALLGOOD
ROBERT E. WATERMAN
Research30 Oct 1986
Nature

Volume: 323, P: 764
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Research04 Jan 2021
Nature Genetics

Volume: 53, P: 65-75
Properdin factor B and histocompatibility loci linked in the rhesus monkey

JOHN B. ZIEGLER
CHESTER A. ALPER
HANS BALNER
Research01 Apr 1975
Nature

Volume: 254, P: 609-611
Monitored long-range interacting systems: spin-wave theory for quantum trajectories

Measurement-induced quantum phases provide prime examples of non-trivial many-body dynamics and collective phenomena, but their experimental detection is difficult due to the post-selection barrier. Here, the authors provide a spin-wave-based approach to monitored quantum dynamics in long-range interacting systems, overcoming this challenge.

Zejian Li
Anna Delmonte
Rosario Fazio
ResearchOpen Access09 May 2025
Nature Communications

Volume: 16, P: 1-11
Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Small non-coding RNAs contribute to the regulation of aging. Here the authors identify a small nucleolar RNA, the snoRNA jouvence, which extends the lifespan of fruit flies through its function in the gut, and is conserved in humans.

Stéphanie Soulé
Lucille Mellottée
Jean-René Martin
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-21
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis

The epigenetic changes underlying the heterogeneity of RA disease presentation have been the subject of intense scrutiny. In this study, the authors use multiple single-cell sequencing datasets to define ‘chromatin superstates’ in patients with RA, which associate with distinct transcription factors and disease phenotypes.

Kathryn Weinand
Saori Sakaue
Soumya Raychaudhuri
ResearchOpen Access31 May 2024
Nature Communications

Volume: 15, P: 1-25
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763

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