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Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

Mammalian oocytes divide asymmetrically during meiotic maturation. Here, the authors show that spindle movement away from oocyte center depends on actin filaments nucleated from the spindle periphery pushing against surrounding mitochondria, which polarizes spontaneously to produce directional spindle motion.

Xing Duan
Yizeng Li
Rong Li
ResearchOpen Access14 Jan 2020
Nature Communications

Volume: 11, P: 1-15
F-actin mechanics control spindle centring in the mouse zygote

How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tension.

Agathe Chaigne
Clément Campillo
Marie-Emilie Terret
ResearchOpen Access04 Jan 2016
Nature Communications

Volume: 7, P: 1-14
Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.

Isma Bennabi
Flora Crozet
Marie-Emilie Terret
ResearchOpen Access03 Apr 2020
Nature Communications

Volume: 11, P: 1-14
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy

Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective autophagy receptors to initiate phagophore formation.

Mario Mauthe
Nicole van de Beek
Fulvio Reggiori
ResearchOpen Access27 Aug 2025
Nature Cell Biology

Volume: 27, P: 1448-1464
Site of the previous meiotic division defines cleavage orientation in the mouse embryo

Berenika Plusa
Joanna B. Grabarek
Magdalena Zernicka-Goetz
Research23 Sept 2002
Nature Cell Biology

Volume: 4, P: 811-815
Vibron-assisted spin excitation in a magnetically anisotropic molecule

Electrically manipulating molecular magnetism is a challenge to overcome for applications in high-density storage. Here, the authors use inelastic electron tunneling spectroscopy to show that a vibron-assisted spin excitation in a nickel-nickelocene complex exceeds a pure spin excitation in energy and amplitude.

N. Bachellier
B. Verlhac
L. Limot
ResearchOpen Access01 Apr 2020
Nature Communications

Volume: 11, P: 1-7
A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte

Asymmetric spindle positioning in female mouse meiosis depends on the assembly of actin networks. Here, Chaigne et al. show by theoretical modelling and artificial manipulation of the oocyte cortex that a narrow stiffness regime is required to correctly position the spindle during meiosis I in the mouse oocyte.

A. Chaigne
C. Campillo
M. E. Terret
Research19 Jan 2015
Nature Communications

Volume: 6, P: 1-10
Thermally induced magnetic order from glassiness in elemental neodymium

Thermal fluctuations associated with higher temperatures normally destroy long-range order, but in some circumstances they can stabilize new ordered phases. This ‘order by disorder’ phenomenon has now been observed in the magnetic phases of neodymium.

Benjamin Verlhac
Lorena Niggli
Alexander A. Khajetoorians
ResearchOpen Access04 Jul 2022
Nature Physics

Volume: 18, P: 905-911
ATG9A protects the plasma membrane from programmed and incidental permeabilization

Claude-Taupin et al. show that ATG9A mediates protection against plasma membrane damage in diverse biological contexts through a mechanism involving IQGAP1 and ESCRTs.

Aurore Claude-Taupin
Jingyue Jia
Vojo Deretic
Research12 Jul 2021
Nature Cell Biology

Volume: 23, P: 846-858
Controlled spin switching in a metallocene molecular junction

Manipulating spin states of molecules in a controllable manner is essential to develop the molecule-based spintronics technologies. Here, Ormaza et al. show how to use the interaction between a single metallocene molecule and a metallic surface to reversibly switch spin from 1 to ½ in a junction.

M. Ormaza
P. Abufager
L. Limot
ResearchOpen Access07 Dec 2017
Nature Communications

Volume: 8, P: 1-8
Differential signaling by alternative HGF isoforms through c-Met: activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis

Regina M Day
Vittoria Cioce
Donald P Bottaro
Research14 Jun 1999
Oncogene

Volume: 18, P: 3399-3406
Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle

Roman et al. demonstrate that crosslinking and contraction of myofibrils mediate the movement of nuclei to the periphery of myofibres, and describe a role for Arp2/3 in organizing desmin.

William Roman
João P. Martins
Edgar R. Gomes
Research11 Sept 2017
Nature Cell Biology

Volume: 19, P: 1189-1201
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

D Marko
S Schätzle
G Eisenbrand
ResearchOpen Access16 Jan 2001
British Journal of Cancer

Volume: 84, P: 283-289
Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade

Rebecca L Pratt
Michael S Kinch
Research25 Oct 2002
Oncogene

Volume: 21, P: 7690-7699
Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity

B Bardot
R Bouarich-Bourimi
F Toledo
Research04 Aug 2014
Oncogene

Volume: 34, P: 2943-2948
Intensified dose of cyclophosphamide with G-CSF support versus standard dose combined with platinum in first-line treatment of advanced ovarian cancer a randomised study from the GINECO group

I Ray-Coquard
D Paraiso
É Pujade-Lauraine
ResearchOpen Access09 Oct 2007
British Journal of Cancer

Volume: 97, P: 1200-1205

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