Fusion of vesicles with the plasma membrane generates omega-shaped intermediates that are thought to either dilate until flat or less frequently, undergo pore closure. Chiang et al.reveal that in chromaffin cells, these structures do not dilate, but change in size before pore closure or shrink until undetectable.
- Hsueh-Cheng Chiang
- Wonchul Shin
- Ling-Gang Wu