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Showing 1–4 of 4 results
Advanced filters: Author: BARRY I. EISENSTEIN Clear advanced filters

  • The increasing levels of antibiotic resistance observed in clinical isolates, coupled with a lack of new drugs coming through the development pipeline, make the problem of antibiotic resistance a global crisis. In this Essay, Davies and colleagues draw up a priority list of urgent steps and future research directions that are needed to tackle this growing problem.

    • Karen Bush
    • Patrice Courvalin
    • Helen I. Zgurskaya
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 9, P: 894-896

  • Caenorhabditis elegans (which haeme auxotrophs), are used to identify the proteins involved in haeme homeostasis. It is shown that the proteins of HRG-1 and its paralogue HRG-4 are essential for haeme homeostasis, as they are novel transmembrane proteins residing in an intracellular department. Transient knockdown of hrg-1 in zebrafish led to hydrocephalus, yolk tube abnormalities, and defects in erythropoesis. The human and worm HRG proteins co-localize, and bind and transport haeme, showing there is evolutionary conservation of its function.

    • Abbhirami Rajagopal
    • Anita U. Rao
    • Iqbal Hamza
    Research
    Nature
    Volume: 453, P: 1127-1131