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Advanced filters: Author: Badr Sokrat Clear advanced filters

Computationally designed GPCR quaternary structures bias signaling pathway activation

Computational modeling and design of G Protein-Coupled Receptor quaternary structures reveals a signaling bias switch at the receptor dimer interface that selectively controls G protein vs β-arrestin activation.

Justine S. Paradis
Xiang Feng
Patrick Barth
ResearchOpen Access11 Nov 2022
Nature Communications

Volume: 13, P: 1-14
Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes

A V2R–βarrestin–Gβγ complex forms at the plasma membrane and translocates to endosomes. This sheds light on G protein subunit translocation and βarr’s role in sustained signaling.

Badr Sokrat
Anthony H. Nguyen
Michel Bouvier
ResearchOpen Access07 Jul 2024
Communications Biology

Volume: 7, P: 1-14
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis

Elodie Blondel-Tepaz
Marie Leverve
Mark G. H. Scott
Research01 Mar 2021
Oncogene

Volume: 40, P: 2243-2257