Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–2 of 2 results
Advanced filters: Author: Bahar Bazeli Clear advanced filters

  • TRPM3 mediates pain, and mutations in the TRPM3 gene cause neurodevelopmental delay and epilepsy. Here, the authors use cryo-EM and functional studies to define an S1–S4 pocket that binds diverse ligands with stereoselective and mutation-dependent effects on channel gating.

    • Bahar Bazeli
    • Alexander V. Shkumatov
    • Janine D. Brunner
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in the peripheral and central nervous systems; however, the effect of cellular redox state on the TRPM3 activity is unknown. Here, the authors reveal that TRPM3 channel activity is bidirectionally modulated by oxidizing and reducing agents, and identify cysteine residues in the extracellular pore loop of TRPM3 that carry the redox-control of the channel.

    • Katharina Held
    • Evelien Van Hoeymissen
    • Joris Vriens
    ResearchOpen Access
    Communications Chemistry
    Volume: 9, P: 1-16