Nature Search

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease

The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response to amyloid deposition, and Csf1 signaling regulates their transition to the amyloid-associated state.

Alberto Ardura-Fabregat
Lance Fredrick Pahutan Bosch
Marco Prinz
ResearchOpen Access14 Jul 2025
Nature Neuroscience

Volume: 28, P: 1688-1703
Microbial network disturbances in relapsing refractory Crohn’s disease

A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 323-336
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Amendments and Corrections07 Mar 2019
Nature Medicine

Volume: 25, P: 701
Intestinal dysbiosis as an intraoperative predictor of septic complications: evidence from human surgical cohorts and preclinical models of peritoneal sepsis

Daniel Spari
Simone N. Zwicky
Guido Beldi
ResearchOpen Access21 Dec 2023
Scientific Reports

Volume: 13, P: 1-16
Neuronal programming by microbiota regulates intestinal physiology

In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.

Yuuki Obata
Álvaro Castaño
Vassilis Pachnis
Research05 Feb 2020
Nature

Volume: 578, P: 284-289
Delving the depths of ‘terra incognita’ in the human intestine — the small intestinal microbiota

The small intestinal microbiota has a key influence on digestion, immunity and nutrient metabolism but is poorly understood in comparison with the faecal and colonic microbiota. This Perspective discusses the features of the small intestinal microbiota, highlighting technical challenges, knowledge gaps and implications for health.

Bahtiyar Yilmaz
Andrew J. Macpherson
Reviews23 Oct 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 22, P: 71-81
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine

Due to a microbiota-dependent increase in intestinal permeability with age, the gut metabolite N⁶-carboxymethyllysine accumulates in the microglia of mouse and human brains. As a result, microglia display increased oxidative stress and mitochondrial dysfunction.

Omar Mossad
Bérénice Batut
Thomas Blank
Research03 Mar 2022
Nature Neuroscience

Volume: 25, P: 295-305
Mucosal or systemic microbiota exposures shape the B cell repertoire

A mouse model of systemic versus mucosal exposure to microbial taxa reveals that the former provokes a flexible B cell response with a diverse immunoglobulin repertoire, whereas the latter generates a more-restricted response.

Hai Li
Julien P. Limenitakis
Andrew J. Macpherson
Research05 Aug 2020
Nature

Volume: 584, P: 274-278
Microbial drivers of DSS variability

Bacterial taxa within the murine gut microbiota affect susceptibility to the widely used dextran sodium sulfate model of colitis.

Andrew J. Macpherson
Bahtiyar Yilmaz
News & Views01 Apr 2022
Nature Microbiology

Volume: 7, P: 478-479
Crosstalk between γδ T cells and the microbiota

This Perspective discusses current knowledge of the complex crosstalk between the microbiota and γδ T cells and future outlooks.

Pedro H. Papotto
Bahtiyar Yilmaz
Bruno Silva-Santos
Reviews02 Aug 2021
Nature Microbiology

Volume: 6, P: 1110-1117
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity

Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the colon improves glucose metabolism.

Theresa V. Rohm
Lena Keller
Claudia Cavelti-Weder
ResearchOpen Access19 Apr 2022
Communications Biology

Volume: 5, P: 1-15
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1

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