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Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development

Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development for wing evolution.

Magdalena Schindler
Christian Feregrino
Francisca M. Real
ResearchOpen Access16 Jul 2025
Nature Ecology & Evolution

Volume: 9, P: 1626-1642
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence conservation.

Mai H. Q. Phan
Tobias Zehnder
Daniel M. Ibrahim
ResearchOpen Access27 May 2025
Nature Genetics

Volume: 57, P: 1524-1534

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Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

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