Although methodologies to modify the cores of numerous heterocycles have recently been investigation, studies of deconstructive ring-openings of the pharmaceutically important pyrazole structure are scarce. Here, the authors present a methodology using iodine and heat to reformat substituted pyrazoles into fused tricyclic azaheterocyclic (pyrazolopyridopyridazin-6-one) scaffolds.
- You Zhou
- Shuang-Gui Lei
- An-Xin Wu
