Here the authors show that alternative splicing of yeast HEH1 precursor mRNA with competing 5’ splice sites requires optimum decoding of the two sites by U5 and U6 snRNAs, supported by specific proteins of B and Bact spliceosomes, implying that closely spaced sites are used for alternative splicing in the core spliceosome.
- Ankita Katoch Banyal
- Poulami Choudhuri
- Shravan Kumar Mishra