Nature Search

Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience

Whether and how parvalbumin-expressing neural population from Basal forebrain (BFPVNs) nuclei play a role in associative learning are not fully understood. Here authors show that BFPVNs mediate aversive associative learning via playing crucial roles in encoding outcome-related information.

Panna Hegedüs
Bálint Király
Balázs Hangya
ResearchOpen Access07 Jun 2024
Nature Communications

Volume: 15, P: 1-20
KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS mutation and bone metastasis

Zoltan Lohinai
Thomas Klikovits
Balazs Hegedus
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-8
Publisher Correction: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types

Tamás Laszlovszky
Dániel Schlingloff
Balázs Hangya
Amendments and Corrections14 Aug 2020
Nature Neuroscience

Volume: 23, P: 1310
Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma

Krisztina Andrea Szigeti
Marcell Baranyi
József Tímár
ResearchOpen Access07 Jan 2026
Scientific Reports

Volume: 16, P: 1-15
Network of large pedigrees reveals social practices of Avar communities

Analysis of ancient DNA from 424 individuals in the Avar period, from the sixth to the ninth century AD, reveals population movement from the steppe and the prolonged existence of a steppe nomadic descent system centred around patrilineality and female exogamy in central Europe.

Guido Alberto Gnecchi-Ruscone
Zsófia Rácz
Zuzana Hofmanová
ResearchOpen Access24 Apr 2024
Nature

Volume: 629, P: 376-383
Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors

Marcell Baranyi
Eszter Molnár
József Tímár
ResearchOpen Access26 Jan 2024
British Journal of Cancer

Volume: 130, P: 1059-1072
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

Multidrug-resistant Escherichia coli have a high frequency of collateral sensitivity to antimicrobial peptides, which may arise from changes in lipopolysaccharide regulation.

Viktória Lázár
Ana Martins
Csaba Pál
Research24 May 2018
Nature Microbiology

Volume: 3, P: 718-731
Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types

Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution.

Tamás Laszlovszky
Dániel Schlingloff
Balázs Hangya
Research22 Jun 2020
Nature Neuroscience

Volume: 23, P: 992-1003
Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial

In an open-label phase 2 trial, patients with non-small-cell lung cancer received neoadjuvant anti-PD-1 with or without anti-LAG-3, showing that curative intent surgery after combined blockade of PD-1 and LAG-3 is feasible, and leads to preliminary clinical responses.

Martin Schuler
Kristof Cuppens
Clemens Aigner
ResearchOpen Access30 Apr 2024
Nature Medicine

Volume: 30, P: 1602-1611
ContScout: sensitive detection and removal of contamination from annotated genomes

It is unclear whether naturally evolved de novo proteins have stable, folded structures. Here, systematic identification and structural modeling of de novo genes, this study reveals that a small subset of these proteins may have well-folded structures, and were likely born with these structures.

Balázs Bálint
Zsolt Merényi
László G. Nagy
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Epigenetic modulation via the C-terminal tail of H2A.Z

Here the authors reveal triple heterogeneity of H2A.Z containing nucleosomes, attributed to interactions involving the C-terminal tail of the histone variant, and demonstrate modulation of global chromatin architecture using a synthetic tail peptide.

László Imre
Péter Nánási Jr
Gábor Szabó
ResearchOpen Access24 Oct 2024
Nature Communications

Volume: 15, P: 1-21
An improved observer design approach for autonomous vehicles using error-based ultra-local model

Daniel Fenyes
Tamas Hegedus
Peter Gaspar
ResearchOpen Access11 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Evolutionary trajectories of small cell lung cancer under therapy

We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.

Julie George
Lukas Maas
Roman K. Thomas
ResearchOpen Access13 Mar 2024
Nature

Volume: 627, P: 880-889
Comparative genomics reveals the origin of fungal hyphae and multicellularity

Hyphae are a major innovation in fungi associated with transitions to multicellularity. Here, Kiss and colleagues use comparative genomic analyses to reconstruct the evolutionary origins of hyphae and the molecular evolution of hypha morphogenesis genes.

Enikő Kiss
Botond Hegedüs
László G. Nagy
ResearchOpen Access09 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Guardians of the learning gate

Unexpected experiences often lead to strong memories. A new study by Krabbe and Paradiso et al. shows that vasoactive intestinal peptide (VIP)-expressing interneurons of the basolateral amygdala control associative learning and memory formation by gating aversive stimuli scaled by their unexpectedness.

Panna Hegedüs
Sergio Martínez-Bellver
Balázs Hangya
News & Views21 Oct 2019
Nature Neuroscience

Volume: 22, P: 1747-1748
Intrathoracic solitary fibrous tumor – an international multicenter study on clinical outcome and novel circulating biomarkers

Bahil Ghanim
Sebastian Hess
György Lang
ResearchOpen Access02 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Thomas Klikovits
Paul Stockhammer
Balazs Hegedus
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold

Póti et al developed cyclic, tuneable and chiral warheads against the protein-protein interaction surface of mitogen-activated protein kinases, which form a reversible covalent bond with nucleophilic surface residues to modulate cellular signaling networks.

Ádám Levente Póti
Dániel Bálint
Attila Reményi
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-22
Intelligent image-based in situ single-cell isolation

The isolation of single cells while retaining context is important for quantifying cellular heterogeneity but technically challenging. Here, the authors develop a high-throughput, scalable workflow for microscopy-based single cell isolation using machine-learning, high-throughput microscopy and laser capture microdissection.

Csilla Brasko
Kevin Smith
Peter Horvath
ResearchOpen Access15 Jan 2018
Nature Communications

Volume: 9, P: 1-7
Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease

Andrea Slézia
Panna Hegedüs
Balázs Hangya
ResearchOpen Access09 Nov 2023
Scientific Reports

Volume: 13, P: 1-17
Multicellular contractility contributes to the emergence of mesothelioma nodules

Julia Tarnoki-Zach
Paul Stockhammer
Andras Czirok
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
Implementation of an experimental isolated lung perfusion model on surgically resected human lobes

Alexis Slama
Christian Raber
Clemens Aigner
ResearchOpen Access21 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Boglárka Zámbó
Zsuzsa Bartos
Balázs Sarkadi
ResearchOpen Access10 May 2018
Scientific Reports

Volume: 8, P: 1-13
Differential effects of hypoxia on motility using various in vitro models of lung adenocarcinoma

Sára Eszter Surguta
Marcell Baranyi
József Tóvári
ResearchOpen Access03 Sept 2024
Scientific Reports

Volume: 14, P: 1-12
In situ lymphoma imaging in a spontaneous mouse model using the Cerenkov Luminescence of F-18 and Ga-67 isotopes

Zsombor Ritter
Katalin Zámbó
Erzsébet Schmidt
ResearchOpen Access14 Dec 2021
Scientific Reports

Volume: 11, P: 1-9
Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition

Bahil Ghanim
Anna Rosenmayr
Clemens Aigner
ResearchOpen Access01 Apr 2020
Scientific Reports

Volume: 10, P: 1-10
Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma

Sabrina Borchert
Pia-Maria Suckrau
Fabian D. Mairinger
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis

Michaela B Kirschner
Emily Pulford
Glen Reid
ResearchOpen Access11 Aug 2015
British Journal of Cancer

Volume: 113, P: 963-969
Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma

B Ghanim
M A Hoda
B Hegedus
ResearchOpen Access16 Jan 2014
British Journal of Cancer

Volume: 110, P: 984-990
Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study

B Ghanim
T Klikovits
B Hegedus
ResearchOpen Access29 Jan 2015
British Journal of Cancer

Volume: 112, P: 783-792

Search

Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience

KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS mutation and bone metastasis

Publisher Correction: Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types

Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma

Network of large pedigrees reveals social practices of Avar communities

Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types

Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial

ContScout: sensitive detection and removal of contamination from annotated genomes

Epigenetic modulation via the C-terminal tail of H2A.Z

An improved observer design approach for autonomous vehicles using error-based ultra-local model

Evolutionary trajectories of small cell lung cancer under therapy

Comparative genomics reveals the origin of fungal hyphae and multicellularity

Guardians of the learning gate

Intrathoracic solitary fibrous tumor – an international multicenter study on clinical outcome and novel circulating biomarkers

Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold

Intelligent image-based in situ single-cell isolation

Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease

Multicellular contractility contributes to the emergence of mesothelioma nodules

Implementation of an experimental isolated lung perfusion model on surgically resected human lobes

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Differential effects of hypoxia on motility using various in vitro models of lung adenocarcinoma

In situ lymphoma imaging in a spontaneous mouse model using the Cerenkov Luminescence of F-18 and Ga-67 isotopes

Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition

Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma

Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis

Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma

Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study

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