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Showing 1–7 of 7 results
Advanced filters: Author: Balca R. Mardin Clear advanced filters

  • Cells employ different repair pathways to repair DNA double strand breaks. Here, the authors develop a CRISPR/Cas9-dependent method to study choices in DNA repair called the Color Assay Tracing-Repair (CAT-R) which simultaneously measure outcomes of DSB repair via end-protection and end-resection pathways.

    • Paris Roidos
    • Stephanie Sungalee
    • Balca R. Mardin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Here the authors measure how the absence of certain DNA repair genes change the frequencies of unique mutational outcomes generated by Cas9 DSBs at synthetic target sequences in mouse embryonic stem cells: they use this to build predictive models of the mutagenic outcomes of Cas9 scission.

    • Ananth Pallaseni
    • Elin Madli Peets
    • Leopold Parts
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Khmelinskii et al. describe tandem fluorescent protein timers for measuring protein turnover and trafficking in living cells. Data from a single time point are used to determine protein stability, allowing the authors to screen for components of protein degradation pathways.

    • Anton Khmelinskii
    • Philipp J Keller
    • Michael Knop
    Research
    Nature Biotechnology
    Volume: 30, P: 708-714

  • The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulation are associated with sustained monosomies.

    • Narendra Kumar Chunduri
    • Paul Menges
    • Zuzana Storchova
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration mapping (CESAM), which they use to identify somatic copy-number alterations affecting cis-regulatory elements in cancer. They find that enhancer hijacking leads to overexpression of IRS4 and IGF2 in cancer.

    • Joachim Weischenfeldt
    • Taronish Dubash
    • Jan O Korbel
    Research
    Nature Genetics
    Volume: 49, P: 65-74